Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 837-52-5, is researched, Molecular C13H14ClN3, about The synthesis of novel hybrid compounds containing 5-nitrothiazole moiety as potential antiparasitic agents, the main research direction is nitrothiazole hybrid compound preparation antiparasitic trichomoniasis giardiasis.Name: 7-Chloro-4-(piperazin-1-yl)quinoline.
Abstract: A number of novel compounds containing 5-nitrothiazole moiety as potential antiparasitic agents have been synthesized through known chem. routes. The structures of the new compounds were confirmed by spectroscopic techniques, 1H NMR, 13C NMR, and mass spectrometry, and by elemental analyses. The prepared compounds were evaluated in vitro for their antigiardial and antitrichomonal activities. All tested compounds exhibited remarkable antigiardial activity with IC50 values ranging from 2.2 to 6.9 μg/cm3 as compared to the reference drug metronidazole (IC50 = 7.3 μg/cm3). In addition, three of the prepared compounds exhibited significant antitrichomonal activity with IC50 values of 4.3, 5.0, and 7.9 μg/cm3, resp., as compared to the reference drug metronidazole (8.5 μg/cm3). Graphical abstract: [Figure not available: see fulltext.].
Different reactions of this compound(7-Chloro-4-(piperazin-1-yl)quinoline)Name: 7-Chloro-4-(piperazin-1-yl)quinoline require different conditions, so the reaction conditions are very important.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary