The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Bromo-3-methyl-1H-indole( cas:1219741-50-0 ) is researched.Computed Properties of C9H8BrN.Zhao, Sen; Li, Chunpu; Xu, Bin; Liu, Hong published the article 《Cp*Rh (III)-catalyzed C-H 3,3-difluoroallylation of indoles and N-iodosuccinimide-mediated cyclization for the synthesis of fluorinated 3,4-dihydropyrimido[1,6-a]indol-1(2H)-one derivatives》 about this compound( cas:1219741-50-0 ) in Youji Huaxue. Keywords: alkoxycarbamoylindole bromodifluoropropene rhodium catalyst difluoroallylation; difluoroallyl alkoxycarbamoylindole preparation iodosuccinimide promoter heterocyclization; difluoroiodomethyl alkoxy pyrimidoindolone preparation. Let’s learn more about this compound (cas:1219741-50-0).
A mild and facile two-step strategy was developed for the synthesis of fluorinated 3,4-dihydropyrimido[1,6-a]indol-1(2H)-ones through Cp*Rh (III)-catalyzed C-H 3,3-difluoroallylation and N-iodosuccinimide (NIS)-mediated cyclization. This strategy featured broad synthetic generality, unique versatility and high efficiency, which provided a potential tool for the construction of fluorine-containing heterocycles for drug discovery.
Different reactions of this compound(6-Bromo-3-methyl-1H-indole)Computed Properties of C9H8BrN require different conditions, so the reaction conditions are very important.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary