Month: April 2022

Name: 8-Bromooctanoic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Mixed Fluorinated/Hydrogenated Self-Assembled Monolayer-Protected Gold Nanoparticles: In Silico and In Vitro Behavior. Author is Marson, Domenico; Guida, Filomena; Sologan, Maria; Boccardo, Silvia; Pengo, Paolo; Perissinotto, Fabio; Iacuzzi, Valentina; Pellizzoni, Elena; Polizzi, Stefano; Casalis, Loredana; Pasquato, Lucia; Pacor, Sabrina; Tossi, Alessandro; Posocco, Paola.

Gold nanoparticles (AuNPs) covered with mixtures of immiscible ligands present potentially anisotropic surfaces that can modulate their interactions at complex nano-bio interfaces. Mixed, self-assembled, monolayer (SAM)-protected AuNPs, prepared with incompatible hydrocarbon and fluorocarbon amphiphilic ligands, are used here to probe the mol. basis of surface phase separation and disclose the role of fluorinated ligands on the interaction with lipid model membranes and cells, by integrating in silico and exptl. approaches. These results indicate that the presence of fluorinated amphiphilic ligands enhances the membrane binding ability and cellular uptake of gold nanoparticles with respect to those coated only with hydrogenated amphiphilic ligands. For mixed monolayers, computational results suggest that ligand phase separation occurs on the gold surface, and the resulting anisotropy affects the number of contacts and adhesion energies with a membrane bilayer. This reflects in a diverse membrane interaction for NPs with different surface morphologies, as determined by surface plasmon resonance, as well as differential effects on cells, as observed by flow cytometry and confocal microscopy. Overall, limited changes in monolayer features can significantly affect NP surface interfacial properties, which, in turn, affect the interaction of SAM-AuNPs with cellular membranes and subsequent effects on cells.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Bisbenzothieno[3,2-b:2′,3′-e]pyridines, published in 2004-09-30, which mentions a compound: 1001-26-9, Name is Ethyl 3-Ethoxy-2-Propenoate, Molecular C7H12O3, Name: Ethyl 3-Ethoxy-2-Propenoate.

Heating potassium 3-aminobenzo[b]thiophene-2-carboxylate with Et propiolate or Et 3-ethoxyacrylate in acetic acid yielded the Et 2-(6,12-Dihydro-bis[1]benzothieno[3,2-b:2′,3′-e]pyridin-6-yl)-acetate (I) as main product and 1,4-dihydro-[1]benzothieno[3,2-b]-4-pyridone as byproduct. The dihydropyridine (DHP) I was dehydrogenated with ammonium cerium nitrate (CAN) to give its pyridine derivative II. The half wave potential E1/2 = 1.64 V showed that I was much more stable against oxidizing agents than the reference compound nifedipine with E1/2 = 1.15 V. Alk. saponification of the acetic acid ester II did not yield the corresponding acetic acid, because decarboxylation took place to form the methylpyridine derivative

In some applications, this compound(1001-26-9)Name: Ethyl 3-Ethoxy-2-Propenoate is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Barnett, David S.; Moquist, Philip N.; Schaus, Scott E. researched the compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol( cas:119707-74-3 ).Synthetic Route of C20H12Br2O2.They published the article 《The Mechanism and an Improved Asymmetric Allylboration of Ketones Catalyzed by Chiral Biphenols》 about this compound( cas:119707-74-3 ) in Angewandte Chemie, International Edition. Keywords: chiral BINOL catalyzed asym allylboration ketone mechanism catalyst exchange. We’ll tell you more about this compound (cas:119707-74-3).

The increase in both rate and enantioselectivity in the chiral BINOL-catalyzed asym. allylboration of PhCOMe with diiso-Pr allylboronate with addition of iso-PrOH was attributed to the exchange reaction of iso-PrOH with iso-Pr (S)-2-phenyl-4-pentenyl BINOL boronate, thus liberating product and starting catalyst. Use of a cyclic allylboronate (2-allyl-1,3,2-dioxaborinane) that would produce a tethered alc. upon catalyst exchange, facilitating catalyst release at end of reaction cycle, and in addition 2 equiv tBuOH relative to ketone, provided (S)-2-phenyl-4-penten-2-ol in near quant. yield and >99:1 e.r.; moreover, the reaction could be run in absence of solvent and the catalyst could be recovered in 90% yield from the reaction.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate( cas:286014-53-7 ) is researched.Safety of 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate.Ernst, Johannes B.; Schwermann, Christian; Yokota, Gen-ichi; Tada, Mizuki; Muratsugu, Satoshi; Doltsinis, Nikos L.; Glorius, Frank published the article 《Molecular Adsorbates Switch on Heterogeneous Catalysis: Induction of Reactivity by N-Heterocyclic Carbenes》 about this compound( cas:286014-53-7 ) in Journal of the American Chemical Society. Keywords: azaheterocyclic carbene adsorbate palladium alumina catalyst activation. Let’s learn more about this compound (cas:286014-53-7).

We report the N-heterocyclic carbene (NHC)-induced activation of an otherwise unreactive Pd/Al2O3 catalyst. Surface anal. techniques demonstrate the NHC being coordinated to the palladium particles and affecting their electronic properties. Ab initio calculations provide further insight into the electronic effect of the coordination with the NHC injecting electron d. into the metal nanocluster thus lowering the barrier for bromobenzene activation. By this NHC modification, the catalyst could be successfully applied in the Buchwald-Hartwig amination of aryl chlorides, bromides, and iodides. Various heterogeneity tests could addnl. show that the reaction proceeds via a heterogeneous active species.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocks. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Antiplasmodial and antitumor activity of dihydroartemisinin analogs derived via the aza-Michael addition reaction. Author is Feng, Tzu-Shean; Guantai, Eric M.; Nell, Margo J.; van Rensburg, Constance E. J.; Hoppe, Heinrich C.; Chibale, Kelly.

A series of dihydroartemisinin derivatives were synthesized via an aza-Michael addition reaction to a dihydroartemisinin-based acrylate and were evaluated for antiplasmodial and antitumor activity. The target compounds showed excellent antiplasmodial activity, with four of the dihydroartemisinin derivatives exhibiting IC50 values of ≤10 nM against both D10 and Dd2 strains of Plasmodium falciparum. Derivative I was the most active against the HeLa cancer cell line, with an IC50 of 0.37 μM and the highest tumor specificity.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C7H12O3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about Side-results in macrocyclic synthesis: template reaction of metal ions with N-(2-aminophenyl)azomethines of β-ketoaldehydes.

o-NH2C6H4NHC:C(CO2Et)C(O)Me (I) underwent a template reaction in the presence of M(OAc)2 (M = Ni, Cu, Co) in MeOH to form II which were characterized by IR, UV, and mass spectra. I was prepared from o-phenylenediamine and ethyl ethoxymethylideneacetate.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 1001-26-9. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about Synthesis of Pyrazolo[1,5-α]pyrimidinone Regioisomers. Author is Gavrin, Lori K.; Lee, Arthur; Provencher, Brian A.; Massefski, Walter W.; Huhn, Stephen D.; Ciszewski, Gregory M.; Cole, Derek C.; McKew, John C..

This work describes two distinct routes to prepare pyrazolo[1,5-α]pyrimidin-7-ones and two distinct routes to prepare pyrazolo[1,5-α]pyrimidin-5-ones. Use of 1,3-dimethyluracil as the electrophile in the preparation of the pyrimidin-5-one regioisomer represents a correction of previously reported results. Also, a novel reaction to prepare this isomer was identified and the reaction mechanism elucidated. This work provides the experimentalist with complimentary synthetic pathways that afford either the pyrimidin-7-one or the pyrimidin-5-one regioisomer.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol, is researched, Molecular C20H12Br2O2, CAS is 119707-74-3, about Asymmetric Petasis Reactions Catalyzed by Chiral Biphenols, the main research direction is alkenyl boronate asym Petasis reaction secondary amine glyoxylate biphenol; amino ester unsaturated asym synthesis.Synthetic Route of C20H12Br2O2.

Chiral biphenols catalyze the enantioselective Petasis reaction of alkenyl boronates R1R2C:CHB(OEt)2 (R1 = n-Bu, cyclohexyl, Ph, 4-MeOC6H4, 3-thienyl, etc., R2 = H; R1 = n-Bu, Ph, R2 = Me), secondary amines R3R4NH (R3 = PhCH2, R4 = Me, t-Bu, CH2CH2CN, EtO2C, Me3Si, PhCH2, etc.; R3 = R4 = allyl; etc.), and Et glyoxylate. The reaction requires the use of 15 mol % of (S)-VAPOL as the catalyst, alkenyl boronates as nucleophiles, Et glyoxylate as the aldehyde component, and 3A mol. sieves as an additive. The chiral α-amino ester products R1R2C:CHCH(NR3R4)CO2Et were obtained in good yields (71-92%) and high enantiomeric ratios (89:11-98:2). Mechanistic investigations indicate single ligand exchange of acyclic boronate with VAPOL and tetracoordinate boronate intermediates.

In some applications, this compound(119707-74-3)Synthetic Route of C20H12Br2O2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of (S)-3,3′-Dibromo-1,1′-bi-2-naphthol. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol, is researched, Molecular C20H12Br2O2, CAS is 119707-74-3, about Mechanism and Stereoselectivity of the BINOL-Catalyzed Allylboration of Skatoles. Author is Huang, Genping; Diner, Colin; Szabo, Kalman J.; Himo, Fahmi.

D. functional theory calculations have been performed to investigate the binaphthol-catalyzed allylboration of skatoles. The high stereoselectivity observed for the reaction is reproduced well by the calculations and was found to be mainly a result of steric repulsions in the corresponding Zimmerman-Traxler transition states. The role of the additive MeOH in enhancing the stereoselectivity was also investigated and is suggested to promote the formation of less reactive allylboronic ester intermediates, thereby suppressing the formation of allylboroxine species, which undergo the facile racemic background reaction.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 8-Bromooctanoic acid(SMILESS: O=C(O)CCCCCCCBr,cas:17696-11-6) is researched.Recommanded Product: 3,4,5-Trichloropyridine. The article 《Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer》 in relation to this compound, is published in European Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:17696-11-6).

In this study, a class of novel HDACs inhibitors I (R = H, 4-CH3OC6H4; R1 = H, C6H5, 4-CH3OC6H4, 4-OHC6H4; R2 = H, OH; X = (CH2)n, n = 1, 3, 4, 5, 6, 7), II•HCl (R3 = N(CH3)2, 4-methylpiperazin-1-yl, morpholin-4-yl, piperidin-1-yl, pyrrolidin-1-yl; Y = (CH2)n, n = 5, 6, 7; Z = (CH2)n, n = 2, 3) was designed and synthesized based on the structure of flavones and isoflavones, followed by biol. evaluation. To be specific, a lead compound II•HCl [R3 = N(CH3)2; Y = (CH2)5; Z = (CH2)2 (III)] was discovered with strong anti-proliferative effects on a variety of solid tumor cells, especially for breast cancer cells with resistance to SAHA. Studies demonstrated that III could significantly inhibit the activity of HDAC 1,2,3 (class I) and 6 (class IIB), leading to a dose-dependent accumulation of acetylated histones and α-Tubulin, cell cycle arrest (G1/S phase) and apoptosis in breast cancer cells. Furthermore, the lead compound III could also antagonize the activation of STAT3 induced by HDACs inhibition in some breast cancer cells, which further reduced the level of pro-survive proteins in tumor cells and enhanced anti-tumor activity regulated by STAT3 signaling in vivo. Overall, findings demonstrated that the novel compound III might be a HDACs inhibitor candidate, which could be used as promising chemotherapeutic agent for breast cancer.

As far as I know, this compound(17696-11-6)Name: 8-Bromooctanoic acid can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary