Month: April 2022

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate, is researched, Molecular C21H25BF4N2, CAS is 286014-53-7, about Copper-Catalyzed Direct Aryl Quaternization of N-Substituted Imidazoles to Form Imidazolium Salts, the main research direction is copper catalyzed quaternization imidazole aryliodonium salt; imidazolium salt preparation; triazolium salt preparation.Application of 286014-53-7.

Diaryliodonium salts are employed to directly quaternize N-substituted imidazoles by using a copper catalyst to construct aryl imidazolium salts in moderate to excellent yields [e.g., N-phenylimidazole + diphenyliodonium tetrafluoroborate in presence of Cu(OAc)2 in DMF afforded 97% 1,3-diphenylimidazolium tetrafluoroborate]. This transformation is tolerant to a broad range of functional groups and provides a straightforward, efficient, and versatile route to synthesize aryl imidazolium as well as triazolium salts, especially the unsym. version.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocks. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol, is researched, Molecular C20H12Br2O2, CAS is 119707-74-3, about Chiral Organic Dyes Endowed with Circularly Polarized Laser Emission. Author is Jimenez, Josue; Cerdan, Luis; Moreno, Florencio; Maroto, Beatriz L.; Garcia-Moreno, Inmaculada; Lunkley, Jamie L.; Muller, Gilles; de la Moya, Santiago.

The direct generation of efficient, tunable, and switchable circularly polarized laser emission (CPLE) would have far-reaching implications in photonics and material sciences. The authors describe the 1st chiral simple organic mols. (SOMs) capable of simultaneously sustaining significant chem. robustness, high fluorescence quantum yields, and circularly polarized luminescence (CPL) ellipticity levels (|glum|) comparable to those of similar CPL-SOMs. All these parameters altogether enable efficient laser emission and CPLE with ellipticity levels 2 orders of magnitude stronger than the intrinsic CPL ones.

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Bromide – Wikipedia,
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Name: 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate, is researched, Molecular C21H25BF4N2, CAS is 286014-53-7, about Expeditious synthesis of [Au(NHC)(L)]+ (NHC = N-heterocyclic carbene; L = phosphine or NHC) complexes. Author is Gaillard, Sylvain; Nun, Pierrick; Slawin, Alexandra M. Z.; Nolan, Steven P..

Deprotonation of imidazolium or tertiary phosphonium salts by the versatile N-heterocyclic carbene (NHC) gold(I) hydroxide [Au(OH)(IPr)] (IPr = N,N’-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) as precursor permits the expedient synthesis of a series of cationic heteroleptic [Au(NHC)(NHC’)]+ and [Au(NHC)(PR3)]+ complexes. Complete characterization by 1H and 13C NMR spectroscopy and by single-crystal x-ray diffraction was performed in order to discern electronic and structural differences between cationic heteroleptic [Au(NHC)(NHC’)]+ and [Au(NHC)(PR3)]+ congeners.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol, is researched, Molecular C20H12Br2O2, CAS is 119707-74-3, about Dianionic Phase-Transfer Catalyst for Asymmetric Fluoro-cyclization.Quality Control of (S)-3,3′-Dibromo-1,1′-bi-2-naphthol.

Inspired by the dicationic nature of the electrophilic fluorinating reagent, Selectfluor, we rationally designed a series of dicarboxylic acid precatalysts, which, when deprotonated, act as anionic phase-transfer catalysts for asym. fluorination of alkenes. Among them, I (n = 1) having the shortest linker moiety efficiently catalyzed unprecedented 6-endo-fluoro-cyclization of various allylic amides, affording fluorinated dihydrooxazine compounds with high enantioselectivity (up to 99% ee). In addition to cyclic substrates, acyclic trisubstituted alkenes underwent the reaction with good diastereoselectivity, whereas low diastereoselectivity was observed for linear disubstituted alkenes. Results suggest that the reaction proceeds via a fluoro-carbocation intermediate.

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Bromide – Wikipedia,
bromide – Wiktionary

Sun, Xiao-Peng; Liu, Tao; Yao, Zi-Shuo; Tao, Jun published the article 《Spin crossover and photomagnetic behaviors in one-dimensional looped coordination polymers》. Keywords: dipyridyl disulfide iron complex preparation spin crossover photomagnetic behavior; coordination polymer dipyridyl disulfide iron complex preparation light induced.They researched the compound: 4,4-Dipyridyl Disulfide( cas:2645-22-9 ).Recommanded Product: 4,4-Dipyridyl Disulfide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2645-22-9) here.

Three one-dimensional looped coordination polymers with the formula of [Fe(dpds)2{C(CN)3}2]·dpds (1, dpds = 4,4′-dipyridyl disulfide), [Fe(dpds)2(NCBH3)2] (2) and [Fe(dpds)2(NCSe)2]·3.5H2O (3) have been synthesized and characterized by single-crystal x-ray crystallog., Moessbauer spectroscopy and magnetic measurements. The spin-crossover (SCO) behaviors of these compounds depend significantly on axial ligands: compound 1 exhibited thermal-induced complete one-step SCO behavior with a T1/2 of 170 K, and 2 showed incomplete SCO behavior with T1/2 being 130 K, whereas 3 was paramagnetic. Meanwhile, both compounds 1 and 2 displayed light-induced excited spin-state trapping (LIESST) effects, featuring TLIESST values of 45 K and 61 K for 1 and 2, resp., which were independent of exciting laser wavelengths. These results suggest that anions such as C(CN)3- and NCBH3- with much stronger ligand fields are needed in order to realize spin-state switching, if a ligand such as dpds is adopted to synthesize SCO compounds

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Aboul-Enein, Mohamed Nabil; Abd El-Sattar El-Azzouny, Aida M.; Abdel-Fattah Ragab, Fatma; Hamissa, Mohamed Farouk published the article 《Design, Synthesis, and Cytotoxic Evaluation of Certain 7-Chloro-4-(piperazin-1-yl)quinoline Derivatives as VEGFR-II Inhibitors》. Keywords: chloropiperazinyl quinoline derivative preparation VEGFR inhibitor cancer; Chloro-4-(piperazin-1-yl)quinolines; Cytotoxic evaluation; Human breast cancer cell line (MCF-7); Human prostate cancer cell line (PC3); VEGFR-II.They researched the compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5 ).HPLC of Formula: 837-52-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:837-52-5) here.

Signaling pathway inhibition of VEGFR-II is visualized as valuable tool in cancer management. In the current study, the synthesis of novel 1-(4-(7-chloroquinolin-4-yl)piperazin-1-yl)-2-(N-substituted-amino)-ethanone derivatives (4a-t) was achieved through the amination of 2-chloro-1-(4-(7-chloroquinolin-4-yl)piperazin-1-yl)ethanone (3) with different secondary amines. The structures of the target compounds were confirmed by IR, 1H-NMR, 13C-NMR, HRMS, and microanal. Compounds 4a-t were subjected to in vitro anticancer screening against human breast cancer (MCF-7) and prostate cancer (PC3) cell lines. The highest cytotoxicty against both cell lines was displayed by 2-(4-(4-bromobenzyl)piperazin-1-yl)-1-(4-(7-chloroquinolin-4-yl)piperazin-1-yl)ethanone (4q), with IC50 values of 6.502 and 11.751 μM against MCF-7 and PC3 cells, resp., compared with the standard drug doxorubicin (MCF-7: 6.774 μM, PC3: 7.7316 μM). Due to its notable activity toward MCF-7 cells, 4q was further evaluated as VEGFR-II inhibitor, showing an IC50 of 1.38 μM compared to sorafenib (0.33 μM). The docking study proved that 4q has a binding mode akin to that of VEGFR-II inhibitors.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of Alkyl Triphenylphosphonium Ostruthin Derivatives as Potential Cytotoxic Candidates, published in 2020-10-12, which mentions a compound: 17696-11-6, Name is 8-Bromooctanoic acid, Molecular C8H15BrO2, Recommanded Product: 17696-11-6.

Ostruthin, isolated from Paramignya trimera, was used as a scaffold to design its alkyl triphenylphosphonium derivatives With the optimal reaction conditions in hand, five alkyl triphenylphosphonium ostruthin derivatives I [n = 3, 4, 5, etc.] were synthesized. Ostruthin and its derivatives I were tested for cytotoxicity against human PANC-1 pancreatic, HeLa cervical, and HepG2 liver cancer cell lines. Ostruthin and its hexyl and heptyl triphenylphosphonium derivatives I [n = 6, 7] showed strong preferential cytotoxicity against PANC-1 cells with the PC50 values of 10.3 and 14.4μM, resp. In addition, compounds I [n = 6, 7] also exhibited potent cytotoxicity towards HeLa cells with the IC50 values of 24.8 and 18.5μM, resp. The hexyl triphenylphosphonium group in I [n = 6] was found to slightly enhance cytotoxicity against HepG2 cells. Further, the morphol. changes and the live-cell imaging result suggested the anticancer potential against HeLa cells of the synthesized ostruthin derivative I [n = 7].

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Bromide – Wikipedia,
bromide – Wiktionary

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3,4,5-Trichloropyridine, is researched, Molecular C5H2Cl3N, CAS is 33216-52-3, about Survey and qualification of internal standards for quantification by 1H NMR spectroscopy.Application In Synthesis of 3,4,5-Trichloropyridine.

In quant. NMR (qNMR) selection of an appropriate internal standard proves to be crucial. In this study, 25 candidate compounds considered to be potent internal standards were investigated with respect to the ability of providing unique signal chem. shifts, purity, solubility, and ease of use. The 1H chem. shift (δ) values, assignments, multiplicities and number of protons (for each signal), appropriateness (as to be used as internal standards) in four different deuterated solvents (D2O, DMSO-d6, CD3OD, CDCl3) were studied. Taking into account the properties of these 25 internal standards, the most versatile eight compounds (2,4,6-triiodophenol, 1,3,5-trichloro-2-nitrobenzene, 3,4,5-trichloropyridine, di-Me terephthalate, 1,4-dinitrobenzene, 2,3,5-triiodobenzoic acid, maleic acid, and fumaric acid) were qualified using both differential scanning calorimetry (DSC) and NMR spectroscopy employing highly pure acetanilide as the reference standard The data from these two methods were compared as well as utilized in the quality assessment of the compounds as internal standards Finally, the selected internal standards were tested and evaluated in a real case of quant. NMR anal. of a paracetamol pharmaceutical product.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate, is researched, Molecular C21H25BF4N2, CAS is 286014-53-7, about Pyridin- and quinolinylidene nickel carbene complexes as effective catalysts for the Grignard cross-coupling reaction.Application In Synthesis of 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate.

Complex compounds that contain N-heterocyclic carbene (NHC) and N-heterocyclic carbene ligands with a remote heteroatom (rNHC) were prepared in good yields and characterized. [Cl(NHC)(PPh3)2Ni]BF4 and [Cl(rNHC)(PPh3)2Ni]BF4 also combine the stability of carbene complexes with the activity of phosphine complexes and some are active and effective precatalysts for aryl-coupling in the Kumada-Corriu reaction. Aryl chlorides can be used as substrates. Their performance in catalysis as well as their easy preparation make the new compounds superior to other comparable mixed carbene-phosphine compounds known thus far.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol(SMILESS: OC1=C(Br)C=C2C=CC=CC2=C1C3=C4C=CC=CC4=CC(Br)=C3O,cas:119707-74-3) is researched.Electric Literature of C31H26FeNOP. The article 《Enantioselective Synthesis of 3,3′-Disubstituted 2-Amino-2′-hydroxy-1,1′-binaphthyls by Copper-Catalyzed Aerobic Oxidative Cross-Coupling》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:119707-74-3).

A challenging direct asym. catalytic aerobic oxidative cross-coupling of 2-naphthylamine and 2-naphthol, using a novel CuI/SPDO system, has been successfully developed for the first time. Enantioenriched 3,3′-disubstituted NOBINs were achieved and could be readily derived to divergent chiral ligands and catalysts. This reaction features high enantioselectivities (up to 96% ee) and good yields (up to 80%). The DFT calculations suggest that the F-H interactions between CF3 of L17 and H-1,8 of 2-naphthol, and the π-π stacking between the two coupling partners could play vital roles in the enantiocontrol of this cross-coupling reaction.

Here is just a brief introduction to this compound(119707-74-3)Product Details of 119707-74-3, more information about the compound((S)-3,3′-Dibromo-1,1′-bi-2-naphthol) is in the article, you can click the link below.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary