Month: April 2022

Li, Shi-ying; Zhu, Xie-fei; Zhang, Li-qiang; Zhu, Xi-feng published the article 《Atmospheric distillation of bio-oil based on different extractants》. Keywords: biomass pyrolytic fuel oil distillation extractive.They researched the compound: Ethyl 3-Ethoxy-2-Propenoate( cas:1001-26-9 ).Name: Ethyl 3-Ethoxy-2-Propenoate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1001-26-9) here.

In order to sep. and enrich the high value-added chems. in bio-oil, solvent extraction and distillation methods were combined to sep. and purify bio-oil. Ethyl-acetate, dichloromethane, di-Et ether and toluene were elected as extracting agents, which were mixed with bio-oil in a certain mass ratio. The 4 oil phases distilled from four extract phases were compared with bio-oil to study effects of different solvents on the yield, moisture and high value-added components of distillate. The results show that the distillate had higher yield and lower moisture content compared with that of bio-oil after the extraction and distillation Among the 4 solvents, toluene had the poorest ability to extract high value-added components of bio-oil, achieving the lowest yield of phenols of distillate. The extraction efficiency of ethyl-acetate and di-Et ether was higher than that of toluene, but the contents of high value-added components in their oil phases were lower than those of others. The relative content of guaiacol and its derivatives was 34.11% in the oil phases of dichloromethane, which was 15.52% higher than that of bio-oil, and conducive to further extract for high value-added chems. such as guaiacol and its derivatives

The article 《Atmospheric distillation of bio-oil based on different extractants》 also mentions many details about this compound(1001-26-9)Name: Ethyl 3-Ethoxy-2-Propenoate, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 2645-22-9. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Response of a Zn(II)-based metal-organic coordination polymer towards trivalent metal ions (Al3+, Fe3+ and Cr3+) probed by spectroscopic methods. Author is Daga, Pooja; Manna, Priyanka; Majee, Prakash; Singha, Debal Kanti; Hui, Sayani; Ghosh, Ananta Kumar; Mahata, Partha; Mondal, Sudip Kumar.

A new zinc-based two-dimensional coordination polymer, [Zn(5-AIP)(Ald-4)]·H2O (5-AIP = 5-amino isophthalate, Ald-4 = aldrithiol-4), 1 , was synthesized at room temperature by the layer diffusion technique. Single-crystal X-ray diffraction anal. of 1 showed a two-dimensional bilayer structure. An aqueous suspension of 1 upon excitation at 300 nm displayed an intense blue emission at 403 nm. The luminescence spectra were interestingly responsive and selective to Al3+, Cr3+ and Fe3+ ions even in the presence of other interfering ions. The calculated detection limits for Al3+, Cr3+ and Fe3+ were 0.35μM (≡8.43 ppb), 0.46μM (≡22.6 ppb) and 0.30μM (≡15.85 ppb), resp. Notably, with the cumulative addition of Al3+ ions, the luminescence intensity at 403 nm decreased steadily with a gradual red shift up to 427 nm. Afterward, this red shifted peak showed a turn-on effect upon further addition of Al3+ ions. However, for Cr3+ and Fe3+ ions, there was only drastic luminescence quenching and a large red shift up to 434 nm. This indicated the formation of a complex between 1 and these metal ions, which was also supported by the UV-Visible absorption spectra of 1 that showed the appearance of a new band at 280 nm in the presence of these three metal ions. The FTIR spectra revealed that these ions interacted with the carboxylate oxygen atom of 5-AIP and the nitrogen atom of the Ald-4 ligand in the structure. The luminescence lifetime decay anal. manifested that a charge-transfer type complex was formed between 1 and Cr3+ and Fe3+ ions that resulted in huge luminescence quenching due to the efficient charge transfer involving the vacant d-orbitals, whereas for Al3+ ions having no vacant d-orbital, turn-on of luminescence occurred because of the increased rigidity of 1 upon complexation.

The article 《Response of a Zn(II)-based metal-organic coordination polymer towards trivalent metal ions (Al3+, Fe3+ and Cr3+) probed by spectroscopic methods》 also mentions many details about this compound(2645-22-9)Recommanded Product: 2645-22-9, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate( cas:286014-53-7 ) is researched.Recommanded Product: 286014-53-7.Gibard, Clementine; Ibrahim, Houssein; Gautier, Arnaud; Cisnetti, Federico published the article 《Simplified Preparation of Copper(I) NHCs Using Aqueous Ammonia》 about this compound( cas:286014-53-7 ) in Organometallics. Keywords: copper imidazolylidene imidazolinylidene preparation water ethanol aqueous ammonia; imidazolium imidazolinium reaction copper halide water ethanol aqueous ammonia. Let’s learn more about this compound (cas:286014-53-7).

The use of aqueous NH3 as a coordinating and basic reagent for the metalation of imidazol(in)ium salts derived from (S)IPr (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene, SIPr = 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene) and (S)IMes (IMes = 1,3-dimesitylimidazol-2-ylidene; SIMes = 1,3-dimesitylimidazolin-2-ylidene) with simple inorganic Cu precursors is reported. The synthesis of Cu N-heterocyclic carbene complexes was performed using aqueous/alc. media in mild conditions (room temperature to 60°) with short reaction times. Heteroleptic bromide and iodide complexes could be prepared efficiently for (S)IPr, while chloride complexes were easily accessible for SIMes and (S)IPr. NH3 also allowed the efficient synthesis of homoleptic [Cu(NHC)2](Y) (NHC = (S)IMes; Y = PF6, BF4) species by a variant procedure in EtOH.

The article 《Simplified Preparation of Copper(I) NHCs Using Aqueous Ammonia》 also mentions many details about this compound(286014-53-7)Recommanded Product: 286014-53-7, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Condensation of carboxylic acid esters with ethoxyacetylene》. Authors are Krasnaya, Zh. A.; Kucherov, V. F..The article about the compound:Ethyl 3-Ethoxy-2-Propenoatecas:1001-26-9,SMILESS:O=C(OCC)/C=C/OCC).Recommanded Product: Ethyl 3-Ethoxy-2-Propenoate. Through the article, more information about this compound (cas:1001-26-9) is conveyed.

To 7.4 g. HCO2Et was added with ice-cooling 6.4 ml. BF3.Et2O, followed by 3.5 g. EtOC:CH and, after 15 min., aqueous NaOAc to yield 31% EtOCH:CHCO2Et, b13 80-2°, n20D 1.4400. Similar reaction of EtOAc gave 29% EtOCMe:CHCO2Et (I), b7 70-2°, n20D 1.4460, m. 30-1°. Iso-BuCO2Et gave a mixture of products from which was isolated, with difficulty, some pure iso-BuC(OEt):CHCO2Et, b4 83-5°, n20D 1.4510. EtOCCH and BF3.Et2O in Et2O with ice-cooling gave in 15 mill. some EtOAc, AcCH2CO2Et, and I. Treatment of BzOMe with BF3 and EtOCCH as above gave 6% Et β-methoxycinnamate, b0.1 78-82°, n20D 1.5210. AcCH2CO2Et in this reaction gave 24% EtO2CCH:CMeCH2CO2Et, b13 124-6°; saponification with aqueous alc. KOH gave mixed cis- and trans-β-methylglutaconic acid, m. 90-107°, from which the trans form, m. 136-8°, was isolated by recrystallization from C6H6.

The article 《Condensation of carboxylic acid esters with ethoxyacetylene》 also mentions many details about this compound(1001-26-9)Recommanded Product: Ethyl 3-Ethoxy-2-Propenoate, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation. Author is Singh, Amandeep; Rani, Anu; Gut, Jiri; Rosenthal, Philip J.; Kumar, Vipan.

A series of piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates were prepared with a view to evaluate their activities against Plasmodium falciparum. The synthesized conjugates had in vitro IC50 values from 0.41 to 2.38 μM against chloroquine-resistant and mefloquine-sensitive W2 strain of P. falciparum. The submicromolar activities of most of the synthesized conjugates suggest that such mol. frameworks can act as therapeutic templates for the design and synthesis of new antimalarials.

The article 《Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation》 also mentions many details about this compound(837-52-5)Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about New piperazine-derived nnrtis as anti-HIV agent: synthesis, biological evaluation and molecular docking studies. Author is Kushwaha, Ram Najar; Debnath, Utsab; Singh, Pankaj; Saxena, Reshu; Gupta, Satish Kumar; Tripathi, Raj Kamal; Siddiqui, Hefazat Husain; Katti, Seturam Bandhacharya.

A new series of piperazine-derived compounds were synthesized and evaluated as HIV-1 reverse transcriptase (HIV-1 RT) inhibitors. Flexibility of the piperazine structure plays an importance role for its diverse pharmacol. properties and medicinal potentialities. Compounds having better inhibitory activities against HIV-1 RT were tested for their anti-HIV activity in TZM-bl cell line. Among tested compounds, 9k exhibited better anti-HIV activity with an IC50 value of 13.18 ± 1.62 μg/mL and a therapeutic index value of 2.26 in TZM-bl cell line. Furthermore, mol. docking anal. revealed the similar binding modes of 9k and delavirdine with HIV-1 RT in which carbonyl group of 9k established hydrogen bonding with Lys103 residue as delavirdine, and other hydrophobic groups were stabilized with hydrophobic area (TRP229, LEU100, TYR188, PHE227, VAL106, PRO236, TYR181, TYR188, TRP229, and TYR318 residues) of HIV-1 RT. Present study suggests that compound 9k may serve as a new lead template for further modification to obtain therapeutically useful mol. for the treatment of HIV infection.

The article 《New piperazine-derived nnrtis as anti-HIV agent: synthesis, biological evaluation and molecular docking studies》 also mentions many details about this compound(837-52-5)Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Application In Synthesis of 4,4-Dipyridyl Disulfide. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Ionic cocrystals of dithiobispyridines: the role of I···I halogen bonds in the building of iodine frameworks and the stabilization of crystal structures. Author is Wzgarda-Raj, Kinga; Nawrot, Martyna; Rybarczyk-Pirek, Agnieszka J.; Palusiak, Marcin.

It has been confirmed that mercaptopyridines undergo spontaneous condensation in redox reaction with iodine-forming dithiopyridines. In the solid state, these compounds are protonated at the N atoms and cocrystallize with iodine forming salt structures, namely, 2-[(pyridin-2-yl)disulfanyl]pyridinium triiodide sesquiiodine, C10H9N2S2+·I3-·1.5I2, and 4,4′-(disulfanediyl)dipyridinium pentaiodide triiodide, C10H10N2S22+·I5-·I3-. Dithiopyridine cations are packed among three-dimensional frameworks built from iodide anions and neutral iodine mols., and are linked by hydrogen, halogen and chalcogen interactions. Quantum chem. computations indicated that dithiopyridines exhibit anomalously high nitrogen basicity which qualify them as potential proton sponges.

The article 《Ionic cocrystals of dithiobispyridines: the role of I···I halogen bonds in the building of iodine frameworks and the stabilization of crystal structures》 also mentions many details about this compound(2645-22-9)Application In Synthesis of 4,4-Dipyridyl Disulfide, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 837-52-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Bisquinolines. 2. Antimalarial N,N-bis(7-chloroquinolin-4-yl)heteroalkanediamines. Author is Vennerstrom, Jonathan L.; Ager, Arba L. Jr.; Dorn, Arnulf; Andersen, Steven L.; Gerena, Lucia; Ridley, Robert G.; Milhous, Wilbur K..

N,N-Bis(7-chloroquinolin-4-yl)heteroalkanediamines I [R = HN(CH2)2O(CH2)2NH, HN(CH2)3O(CH2)4O(CH2)3NH, HN(CH2)6NH(CH2)6NH, etc.] were synthesized and screened against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. These bisquinolines had IC50 values from 1 to 100 nM against P. falciparum in vitro. Six of the 11 bisquinolines were significantly more potent against the chloroquine-resistant W2 clone compared to the chloroquine-sensitive D6 clone. For bisquinolines I, there was no relationship between the length of the bisquinoline heteroalkane bridge and antimalarial activity and no correlation between in vitro and in vivo antimalarial activities. Bisquinolines with alkyl ether and piperazine bridges were substantially more effective than bisquinolines with alkylamine bridges against P. berghei in vivo. Ten of the bisquinolines were potent inhibitors of hematin polymerization with IC50 values falling in the narrow range of 5-20 μM, and there was a correlation between potency of inhibition of hematin polymerization and inhibition of parasite growth. Compared to alkane-bridged bisquinolines (Vennerstrom et al., 1992), none of these heteroalkane-bridged bisquinolines had sufficient antimalarial activity to warrant further investigation of the series.

The article 《Bisquinolines. 2. Antimalarial N,N-bis(7-chloroquinolin-4-yl)heteroalkanediamines》 also mentions many details about this compound(837-52-5)Application of 837-52-5, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group, published in 2012-08-15, which mentions a compound: 837-52-5, mainly applied to antidiabetic DPP4 inhibitor heteroarylpiperazine prolylthiazolidine preparation structure activity, Application of 837-52-5.

Hypoglycemic agents with a mechanism of dipeptidyl peptidase IV (DPP-4) inhibition are suitable for once daily oral dosing. It is difficult to strike a balance between inhibitory activity and duration of action in plasma for inhibitors bearing an electrophilic nitrile group. We explored fused bicyclic heteroarylpiperazine substituted at the γ-position of the proline structure in the investigation of L-prolylthiazolidines lacking the electrophilic nitrile. Among them, 2-trifluoroquinolyl compound 8g is the most potent, long-lasting DPP-4 inhibitor (IC50 = 0.37 nmol/L) with high selectivity against other related peptidases. X-ray crystal structure determination of 8g indicates that CH-π interactions generated between the quinolyl ring and the guanidinyl group of Arg358 enhances the DPP-4 inhibitory activity and selectivity.

The article 《Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group》 also mentions many details about this compound(837-52-5)Application of 837-52-5, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol( cas:119707-74-3 ) is researched.Synthetic Route of C20H12Br2O2.Yokota, Kazuaki; Kakuchi, Toyoji; Yamamoto, Toshiya; Hasegawa, Toshiyuki; Haba, Osamu published the article 《Asymmetric induction arising from the chiral twist of 2,2′-binaphthyl template in the cyclopolymerization of divinyl ethers》 about this compound( cas:119707-74-3 ) in Makromolekulare Chemie. Keywords: cationic cyclopolymn vinyl ether binaphthyl; chiral twist cyclopolymn binaphthyl vinyl; polymerization cyclo vinyl ether binaphthyl; template cyclopolymn asym induction. Let’s learn more about this compound (cas:119707-74-3).

Cationic cyclopolymn. of divinyl ethers, which were derived from (R)- or (S)-1,1′-bi-2-naphthol with Me, Ph, and bromo groups in the 3,3′-positions, yielded polymers with changing optical rotation according to the reaction conditions. Model compounds corresponding to the 3 stereoisomeric forms of the constitutional units, i.e., 2 racemic (R,R- and S,S-) forms and 1 meso form, were prepared to confirm the origin of changing optical rotation due to the configuration, which had a tendency to be preferentially a racemic-diisotactic structure at higher monomer concentrations and in less polar solvents. The chiral twist of the (R)- or (S)-binaphthyl template induced the main chain to form an asym. R,R- or S,S-racemic sequence, resp., in the cyclopolymn.

The article 《Asymmetric induction arising from the chiral twist of 2,2′-binaphthyl template in the cyclopolymerization of divinyl ethers》 also mentions many details about this compound(119707-74-3)Synthetic Route of C20H12Br2O2, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary