Month: April 2022

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called One-Pot Asymmetric Synthesis of Alkylidene 1-Alkylindan-1-ols Using Bronsted Acid and Palladium Catalysis, published in 2017-11-03, which mentions a compound: 119707-74-3, mainly applied to asym synthesis alkylmethyleneindanol Bronsted acid palladium catalysis; enantioselective allylboration Mizoroki Heck bromoaryl ketone, HPLC of Formula: 119707-74-3.

A one-pot catalytic enantioselective allylboration/Mizoroki-Heck reaction of 2-bromoaryl ketones has been developed for the asym. synthesis of 3-methyleneindanes bearing a tertiary alc. center. Bronsted acid-catalyzed allylboration with a chiral BINOL derivative was followed by a palladium-catalyzed Mizoroki-Heck cyclization, resulting in selective formation of the exo-alkene. This novel protocol provides a concise and scalable approach to 1-alkyl-3-methyleneindan-1-ols in high enantiomeric ratios (up to 96:4 er). The potential of these compounds as chiral building blocks was demonstrated with efficient transformation to optically active diol and amino alc. scaffolds.

The article 《One-Pot Asymmetric Synthesis of Alkylidene 1-Alkylindan-1-ols Using Bronsted Acid and Palladium Catalysis》 also mentions many details about this compound(119707-74-3)HPLC of Formula: 119707-74-3, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Nayak, Rashmi Ashwathama; Bhat, Sachin A.; Shanker, G.; Rao, D. S. Shankar; Yelamaggad, C. V. published an article about the compound: 8-Bromooctanoic acid( cas:17696-11-6,SMILESS:O=C(O)CCCCCCCBr ).SDS of cas: 17696-11-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:17696-11-6) through the article.

Herein the authors report on the synthesis and characterization of four new series of optically active, nonsym. dimers in which cholesterol is covalently linked to a Schiff base core through an ω-oxyalkanoyl spacer. While the Schiff base core is substituted with n-butyloxy, n-hexyloxy, n-octyloxy, n-decyloxy and n-dodecyloxy tails, three even-parity spacers, namely, 4-oxybutanoyl, 6-oxyhexanoyl, 8-oxyoctanoyl, and an odd-parity spacer, namely, 5-oxypentanoyl, were used to join the two cores. The length and parity of the spacer and the length of the terminal tail play a vital role in deciding the phase sequences of the dimers. In general, the dimers possessing an even-parity spacer display enantiotropic LC phases such as chiral nematic (N*), twist grain boundary (TGB), smectic A (SmA), chiral smectic C (SmC*) and twist grain boundary phase with SmC* slabs (TGBC*). Some of these dimers display TGBC* over a wide temperature range. The dimers with an odd-parity (5-oxypentanoyl) spacer display, unlike their even-membered counterparts, blue phases (BPIII/II/I); besides, they stabilize N* and/or unknown smectic (SmX) phases. The CD measurements were carried out as a function of temperature on the planar texture formed by three even-membered dimers and an odd-membered dimer. The occurrence of a strong neg. CD band in the N* phase of the even-membered dimers suggests a left-handed screw sense of the macroscopic helical structure, and the scenario is opposite in the case of an odd-membered dimer.

The article 《Highly frustrated liquid crystal phases in optically active dimers: synthesis and rich phase transitional behavior》 also mentions many details about this compound(17696-11-6)SDS of cas: 17696-11-6, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Asymmetric Propargylation of Ketones Using Allenylboronates Catalyzed by Chiral Biphenols, published in 2011-08-05, which mentions a compound: 119707-74-3, mainly applied to homopropargylic alc enantioselective preparation; ketone allenylboronate asym propargylation biphenol catalyst, Safety of (S)-3,3′-Dibromo-1,1′-bi-2-naphthol.

Chiral biphenols catalyze the enantioselective asym. propargylation of ketones using allenylboronates. The reaction uses 10 mol % of 3,3′-Br2-BINOL as the catalyst and allenyldioxoborolane as the nucleophile, in the absence of solvent, and under microwave irradiation to afford the homopropargylic alc., e.g., I. The reaction products are obtained in good yields (60-98%) and high enantiomeric ratios (3:1-99:1). Diastereoselective propargylations using chiral racemic allenylboronates result in good diastereoselectivities (dr >86:14) and enantioselectivities (er >92:8) under the catalytic conditions.

The article 《Asymmetric Propargylation of Ketones Using Allenylboronates Catalyzed by Chiral Biphenols》 also mentions many details about this compound(119707-74-3)Safety of (S)-3,3′-Dibromo-1,1′-bi-2-naphthol, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, U.S. Gov’t, Non-P.H.S., Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Depolymerization of Hydroxylated Polymers via Light-Driven C-C Bond Cleavage, Author is Nguyen, Suong T.; McLoughlin, Elizabeth A.; Cox, James H.; Fors, Brett P.; Knowles, Robert R., which mentions a compound: 17696-11-6, SMILESS is O=C(O)CCCCCCCBr, Molecular C8H15BrO2, SDS of cas: 17696-11-6.

The accumulation of persistent plastic waste in the environment is widely recognized as an ecol. crisis. New chem. technologies are necessary both to recycle existing plastic waste streams into high-value chem. feedstocks and to develop next-generation materials that are degradable by design. Here, we report a catalytic methodol. for the depolymerization of a com. phenoxy resin and high mol. weight hydroxylated polyolefin derivatives upon visible light irradiation near ambient temperature Proton-coupled electron transfer (PCET) activation of hydroxyl groups periodically spaced along the polymer backbone furnishes reactive alkoxy radicals that promote chain fragmentation through C-C bond β-scission. The depolymerization produces well-defined and isolable product mixtures that are readily diversified to polycondensation monomers. In addition to controlling depolymerization, the hydroxyl group modulates the thermomech. properties of these polyolefin derivatives, yielding materials with diverse properties. These results demonstrate a new approach to polymer recycling based on light-driven C-C bond cleavage that has the potential to establish new links within a circular polymer economy and influence the development of new degradable-by-design polyolefin materials.

The article 《Depolymerization of Hydroxylated Polymers via Light-Driven C-C Bond Cleavage》 also mentions many details about this compound(17696-11-6)SDS of cas: 17696-11-6, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C8H15BrO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Regioselective Hydroformylation of Internal and Terminal Alkenes via Remote Supramolecular Control. Author is Linnebank, Pim R.; Ferreira, Stephan Falcao; Kluwer, Alexander M.; Reek, Joost N. H..

Herein, the redesign of a supramol. Rh-bisphosphite hydroformylation catalyst containing a neutral carboxylate receptor (DIM pocket) with a larger distance between the phosphite metal binding moieties and the DIM pocket was reported. For the first time regioselective hydroformylation of internal CH3(CH2)nCH:CH(CH2)7C(O)OH (n = 3, 5, 7), CH3CH:CH(CH2)nC(O)OH (n = 6, 7) and terminal CH2:CH(CH2)nC(O)OH (n = 2, 3, 4, etc.) alkenes containing a remote carboxylate directing group is demonstrated. For carboxylate substrates that possess an internal double bond at the Δ-9 position, regioselectivity was observed As such, the catalyst was used to hydroformylate natural monounsaturated fatty acids (MUFAs) in a regioselective fashion, forming of an excess of the 10-formyl product (10-formyl/9-formyl product ratio of 2.51), which is the first report of a regioselective hydroformylation reaction of such substrates.

The article 《Regioselective Hydroformylation of Internal and Terminal Alkenes via Remote Supramolecular Control》 also mentions many details about this compound(17696-11-6)Formula: C8H15BrO2, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of new 4-aminoquinolines and quinoline-acridine hybrids as antimalarial agents》. Authors are Kumar, Ashok; Srivastava, Kumkum; Raja Kumar, S.; Puri, S. K.; Chauhan, Prem M. S..The article about the compound:7-Chloro-4-(piperazin-1-yl)quinolinecas:837-52-5,SMILESS:C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3).Formula: C13H14ClN3. Through the article, more information about this compound (cas:837-52-5) is conveyed.

In the present study, new side chain modified 4-aminoquinoline derivatives and quinoline-acridine hybrids were synthesized and evaluated in vitro against NF 54 strain of Plasmodium falciparum. Among the evaluated compounds, one compound (MIC = 0.125 μg/mL) was equipotent to standard drug CQ (MIC = 0.125 μg/mL) and it showed the curative response to all the treated swiss mice infected with CQ-resistant N-67 strain of Plasmodium yoelii at the doses 50 mg/kg and 25 mg/kg for four days by i.p. route and was found to be orally active at the dose of 100 mg/kg for four days. Another compound (MIC = 0.031 μg/mL) was four times more potent than CQ. The promising antimalarial potency of these compounds highlight the significance of exploring the privileged 4-aminoquinoline class for new antimalarials.

The article 《Synthesis of new 4-aminoquinolines and quinoline-acridine hybrids as antimalarial agents》 also mentions many details about this compound(837-52-5)Formula: C13H14ClN3, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C9H8BrN. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Cu-Catalyzed Dimerization of Indole Derived Oxime Acetate for Synthesis of Biimidazo[1,2-a]indoles. Author is Xie, Tao; Sui, Qi-Bang; Qin, Lu-Zhe; Wen, Xiaoan; Sun, Hongbin; Xu, Qing-Long; Zhen, Le.

A copper-mediated cyclization and dimerization of indole derived oxime acetate was developed to generate a series of biimidazo[1,2-a]indole scaffolds with two contiguous stereogenic quaternary carbons in one step.

The article 《Cu-Catalyzed Dimerization of Indole Derived Oxime Acetate for Synthesis of Biimidazo[1,2-a]indoles》 also mentions many details about this compound(1219741-50-0)Computed Properties of C9H8BrN, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C5H2Cl3N. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3,4,5-Trichloropyridine, is researched, Molecular C5H2Cl3N, CAS is 33216-52-3, about Halogen bonding in substituted cobaloximes. Author is Rubin-Preminger, J. M.; Englert, U..

Aquabis(dimethylglyoximato)nitrocobalt(III) reacts with halogen-substituted pyridines to give nitro complexes in which the pyridine donors substitute the aqua ligand; reaction with halogen-substituted pyridinium chlorides directly displaces both the coordinated H2O mol. and the nitro ligand in a 1-pot reaction and affords the analogous chloro complexes. Ten crystal structures of eight new compounds are reported: among these, the nitro complex bis(dimethylglyoximato)nitro(4-chloropyridine)cobalt(III) was characterized by a remarkably long bond between the metal and the nitro ligand whereas the analogous chloro complex chlorobis(dimethylglyoximato)(4-chloropyridine)cobalt(III) features a very long Co-Cl distance. The structures communicated comprise three isomorphous pairs which are particularly suited for the comparative study of chloro and bromo derivatives The most relevant intermol. interactions in these compounds are due to very short O···halogen contacts of ∼2.9 Å whereas shortest interhalogen distances are slightly longer than the sum of the van der Waals radii. For both types of interactions, contact distances involving Br are shorter than those associated with Cl.

The article 《Halogen bonding in substituted cobaloximes》 also mentions many details about this compound(33216-52-3)Synthetic Route of C5H2Cl3N, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 17696-11-6, is researched, Molecular C8H15BrO2, about The design of a novel near-infrared fluorescent HDAC inhibitor and image of tumor cells, the main research direction is fluorescent HDAC inhibitor preparation tumor imaging; HDAC; NIR; Probe; Tumor imaging.Recommanded Product: 17696-11-6.

Histone deacetylases (HDACs) have been found to be biomarkers of cancers and the corresponding inhibitors have attracted much attention these years. Herein we reported a near-IR fluorescent HDAC inhibitor based on vorinostat (SAHA) and a NIR fluorophore. This newly designed inhibitor showed similar inhibitory activity to SAHA against three HDAC isoforms (HDAC1, 3, 6). The western blot assay showed significant difference in compared with the neg. group. When used as probe for further kinematic imaging, Probe 1 showed enhanced retention in tumor cells and the potential of HDAC inhibitors in drug delivery was firstly brought out. The cytotoxicity assay showed Probe 1 had some anti-proliferation activities with corresponding IC50 values of 9.20 ± 0.96μM on Hela cells and 5.91 ± 0.57μM on MDA-MB-231 cells. These results indicated that Probe 1 could be used as a potential NIR fluorescent in the study of HDAC inhibitors and lead compound for the development of visible drugs.

The article 《The design of a novel near-infrared fluorescent HDAC inhibitor and image of tumor cells》 also mentions many details about this compound(17696-11-6)Recommanded Product: 17696-11-6, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 119707-74-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol, is researched, Molecular C20H12Br2O2, CAS is 119707-74-3, about Enantioselective addition of diethylzinc to benzaldehyde catalyzed by (S)-3,3′-disubstituted BINOL.

New chiral ligands (S)-3,3′-di(X)-1,1′-bis(2-naphthol) (X = cyano, bromo, or methyl) were synthesized from (S)-3,3′-diformyl-2,2′-dimethoxy-1,1′-binaphthyl by substitution reaction and demethylation with high yield. The catalytic properties and mechanism of the synthetic chiral ligand (X = cyano) during the enantioselective addition reaction of diethylzinc with benzaldehyde were studied. Moderate-to-good yields with lower enantioselectivities were observed

After consulting a lot of data, we found that this compound(119707-74-3)HPLC of Formula: 119707-74-3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary