Month: April 2022

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Bioorganic & Medicinal Chemistry Letters called Synthesis of 7-chloro-4-substituted aminoquinolines and their in vitro ability to produce methemoglobin in canine hemolyzate, Author is Srivastava, Sandhya; Tewari, Swati; Srivastave, Sanjay K.; Chauhan, P. M. S.; Bhaduri, A. P.; Puri, S. K.; Pandey, V. C., which mentions a compound: 837-52-5, SMILESS is C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3, Molecular C13H14ClN3, Formula: C13H14ClN3.

Synthesis of aminoquinoline derivatives and their in vitro effects on metHb formation and metHb reductase activity are delineated. Some of the screened compounds have shown considerable metHb toxicity. An example compound thus prepared was 2-[(7-chloro-4-quinolinyl)amino]ethanol.

Although many compounds look similar to this compound(837-52-5)Formula: C13H14ClN3, numerous studies have shown that this compound(SMILES:C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Nunes, Renata C.; Araujo, Maria H.; dos Santos, Eduardo N. researched the compound: 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate( cas:286014-53-7 ).HPLC of Formula: 286014-53-7.They published the article 《The unique behavior of the catalytic system Pd(OAc)2/N-heterocyclic carbene on the telomerization of isoprene with methanol》 about this compound( cas:286014-53-7 ) in Catalysis Communications. Keywords: palladium heterocyclic carbene catalyst telomerization isoprene methanol. We’ll tell you more about this compound (cas:286014-53-7).

The catalytic system Pd(OAc)2/1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride (IMes · HCl) promotes the telomerization of isoprene with methanol resulting in methoxy-dimers with a head-to-head coupling of the isoprene units at unprecedented activity and selectivity. Employing 1,3-bis(2,6-di-i-propylphenyl)-4,5-dihydroimidazolium tetrafluoroborate (SIPr·HBF4) instead of IMes·HCl, new sesquiterpenes are obtained by the trimerization of isoprene.

Although many compounds look similar to this compound(286014-53-7)HPLC of Formula: 286014-53-7, numerous studies have shown that this compound(SMILES:CC1=C([N+]2=CN(C3=C(C)C=C(C)C=C3C)C=C2)C(C)=CC(C)=C1.F[B-](F)(F)F), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Le Gall, Tatiana; Baltatu, Sandra; Collins, Shawn K. researched the compound: 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate( cas:286014-53-7 ).Application In Synthesis of 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate.They published the article 《Synthesis of mono- and bis-N-heterocyclic carbene copper(I) complexes via decarboxylative generation of carbenes》 about this compound( cas:286014-53-7 ) in Synthesis. Keywords: nitrogen heterocyclic carbene copper preparation; imidazoliumcarboxylate decarboxylation copper salt. We’ll tell you more about this compound (cas:286014-53-7).

Zwitterionic imidazoliumcarboxylates were thermally decarboxylated in the presence of Cu salts to form NHC-Cu complexes. The selective formation of either mono- or bis-NHC complexes is possible through simple control of the molar equivalents of the Cu salt. A variety of different NHC ligands with either saturated or unsaturated backbones or bearing N-aryl or N-alkyl substituents were complexed to Cu. Thirteen mono- and bis(imidazolylidene) copper(I) complexes were prepared in 41% to 91% yield. E.g., decarboxylation of 1,3-bis(mesityl)imidazolium-2-carboxylate in the presence of [Cu(MeCN)4]BF4 afforded [(Mes2C3H2N2)Cu]BF4 in 91% yield.

Although many compounds look similar to this compound(286014-53-7)Application In Synthesis of 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate, numerous studies have shown that this compound(SMILES:CC1=C([N+]2=CN(C3=C(C)C=C(C)C=C3C)C=C2)C(C)=CC(C)=C1.F[B-](F)(F)F), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 119707-74-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol, is researched, Molecular C20H12Br2O2, CAS is 119707-74-3, about Synthesis and chromatographic evaluation of new polymeric chiral stationary phases based on three (1S,2S)-(-)-1,2-diphenylethylenediamine derivatives in HPLC and SFC. Author is Payagala, Tharanga; Wanigasekara, Eranda; Armstrong, Daniel W..

Three new polymeric chiral stationary phases were synthesized based on (1S,2S)-1,2-bis(2,4,6-trimethylphenyl)ethylenediamine, (1S,2S)-1,2-bis(2-chlorophenyl)ethylenediamine, and (1S,2S)-1,2-di-1-naphthylethylenediamine via a simple free-radical-initiated polymerization in solution These monomers are structurally related to (1S,2S)-1,2-diphenylethylenediamine which is the chiral monomer used for the com. P-CAP-DP polymeric chiral stationary phase (CSP). The performance of these three new chiral stationary phases were evaluated in normal phase HPLC and supercritical fluid chromatog. and the results were compared with those of the P-CAP-DP column. All three new phases showed enantioselectivity for a large number of racemates with a variety of functional groups, including amines, amides, alcs., amino acids, esters, imines, thiols, and sulfoxides. In normal phase, 68 compounds were separated with 28 baseline separations (Rs ≥ 1.5) and in SFC, 65 compounds were separated with 24 baseline separations In total 72 out of 100 racemates were separated by these CSPs with 37 baseline separations Complimentary separation capabilities were observed for many analytes. The new polymeric CSPs showed similar or better enantioselectivities compared with the com. column in both HPLC and SFC. However, faster separations were achieved on the new stationary phases. Also, these polymeric stationary phases have good sample loading capacities while maintaining enantioselectivity.

Although many compounds look similar to this compound(119707-74-3)HPLC of Formula: 119707-74-3, numerous studies have shown that this compound(SMILES:OC1=C(Br)C=C2C=CC=CC2=C1C3=C4C=CC=CC4=CC(Br)=C3O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Ma, Rui; Guo, Dong-Xiao; Li, Hui-Fen; Liu, Hui-Xiang; Zhang, Yun-Rui; Ji, Jian-Bo; Xing, Jie; Wang, Shu-Qi published the article 《Spectroscopic methodologies and molecular docking studies on the interaction of antimalarial drug piperaquine and its metabolites with human serum albumin》. Keywords: spectroscopy mol docking piperaquine metabolite interaction human serum albumin; Human serum albumin (HSA); Interaction; Metabolites; Molecular docking; Piperaquine.They researched the compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5 ).Application of 837-52-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:837-52-5) here.

Artemisinin-based combination therapy is widely used for the treatment of uncomplicated Plasmodium falciparum malaria, and piperaquine (PQ) is one of the important partner drugs. During the biotransformation of PQ, M1 (N-oxidation product), M2 (N-oxidation product), M3 (carboxylic acid product), M4 (N-dealkylation product), and M5 (N-oxidated product of M4) are formed by cytochrome P 450 pathways. Despite decades of clin. use, the interactions between PQ and its main metabolites (PQs) with human serum albumin (HSA) have not been reported. In the present study, the binding of PQs with HSA under physiol. conditions was investigated systematically through fluorescence, CD spectroscopy, and mol. docking methods. The exptl. results show that the intrinsic fluorescence quenching of HSA was induced by those compounds resulting from the formation of stable HSA-compound complexes. The main forces involved in the interactions between PQ, M1, and M2 which bind to HSA were hydrogen s and van der Waals forces, while the interactions of M3, M4, and M5 were driven by hydrophobic forces. The main binding sites of the compounds to HSA were also examined by classical fluorescent marker experiments and mol. docking studies. Binding constants (Kb) revealed that the affinities of the PQ, M1, M2, M3, and M4 to HSA were stronger than that of M5. Addnl., the binding rates of PQs with HSA were determined by ultrafiltration methods. Consistent with the binding constant results, the binding rate of M5 was lower than the binding rates of PQ, M1, M2, M3, and M4. Furthermore, PQs binding to HSA led to conformational and structural alterations of HSA, as revealed by multi-spectroscopic studies. In order to investigate one possible mechanism by which PQs inhibit the growth of malaria-causing Plasmodium parasites, 1H NMR spectroscopy was performed to investigate the interaction of the PQs with heme. This study is beneficial to enhance our understanding of the ecotoxicol. and environmental behaviors of PQ and its metabolites.

Although many compounds look similar to this compound(837-52-5)Application of 837-52-5, numerous studies have shown that this compound(SMILES:C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline(SMILESS: C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3,cas:837-52-5) is researched.Formula: C21H25BF4N2. The article 《Antiparasitic agents. Part VI. Synthesis of 7-chloro-4-(4-substituted-phenylamino)- and 7-chloro-4-(4-substituted-piperazin-1-yl)quinolines as potential antiparasitic agents》 in relation to this compound, is published in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:837-52-5).

Chloro(hydroxyphenylamino)quinolines I (R = H, CO2H, NO2, NH2, substituted carbamoyl, R1 = H, C6H4OMe-2, C6H4Me-3, C6H4Me-4), chloro(4-piperazinyl)quinolines II (R2 = H, substituted carbamoyl, substituted carbamoylmethyl), and other similar compounds were prepared and tested for their antimalarial, antifilarial and antimicrobial activities but none of them shows any noteworthy activity.

Although many compounds look similar to this compound(837-52-5)Electric Literature of C13H14ClN3, numerous studies have shown that this compound(SMILES:C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C21H25BF4N2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate, is researched, Molecular C21H25BF4N2, CAS is 286014-53-7, about Synthesis and Evaluation of Azolium-Based Halogen-Bond Donors. Author is Squitieri, Richard A.; Fitzpatrick, Keegan P.; Jaworski, Ashley A.; Scheidt, Karl A..

A method for the synthesis of iodinated imidazolium and triazolium N-heterocyclic halogen-bond-donor catalysts was developed. This approach was applied to the synthesis of a variety of 1,2,4-triazolium salts to prepare a series of novel chiral halogen-bond-donor catalysts. The counterions of the iodinated triazoliums were readily exchanged with chiral and achiral non-coordinating counterions to produce unique scaffolds. Their ability to promote/catalyze a conjugate addition reaction with indole was investigated. Through these initial studies, a set of general guidelines and considerations for the application of these halogen-bond donors in organocatalysis was established.

Although many compounds look similar to this compound(286014-53-7)Formula: C21H25BF4N2, numerous studies have shown that this compound(SMILES:CC1=C([N+]2=CN(C3=C(C)C=C(C)C=C3C)C=C2)C(C)=CC(C)=C1.F[B-](F)(F)F), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol( cas:119707-74-3 ) is researched.Electric Literature of C20H12Br2O2.Chinnaraja, Eswaran; Arunachalam, Rajendran; Pillai, Renjith S.; Peuronen, Anssi; Rissanen, Kari; Subramanian, Palani S. published the article 《One-pot synthesis of [2+2]-helicate-like macrocycle and 2+4-μ4-oxo tetranuclear open frame complexes: Chiroptical properties and asymmetric oxidative coupling of 2-naphthols》 about this compound( cas:119707-74-3 ) in Applied Organometallic Chemistry. Keywords: one pot helicate macrocycle tetranuclear open frame copper complex; chiroptical asym oxidative coupling naphthol; binaphthyldiamine methyl diformylphenol copper salt self assembly cyclocondensation. Let’s learn more about this compound (cas:119707-74-3).

Synthesis of binuclear Cu(II) terminally closed [2+2]-double-stranded helicate-like macrocycles 1,1′,1”,2,2′,2” and 2+4-μ4-oxo tetranuclear open frame complexes 3,3′,3”,4,4′,4” are established. Adapting one-pot self-assembly technique from simple three components systems: 1,1′-binaphthyl-2,2′-diamine, 4-methyl-2,6-diformyl phenol and cupric salts, the helicate-like [2+2]- macrocyclic complexes 1-1”, 2-2” and 2+4-μ4-oxo tetranuclear complexes 3-3”, 4-4” were obtained by appropriately altering the reaction condition such as temperature and subcomponent ratio. D. Functional Theory (DFT) calculations were carried out for understanding the structural geometries, intermediates involved in the diverse formation of [2+2] and 2+4 frameworks. The single crystal x-ray structures obtained for 1′, 2 and 3 confirms the self-assembly process in line with DFT. This detailed anal. tempted us to derive a plausible mechanism for this long standing challenge in the synthesis of such macrocycles using 1,1′-binaphthyl-2,2′-diamine (BNDA) and aromatic aldehyde. The chiroptical properties of enantiopure complexes and their catalytic applications in asym. oxidative coupling of 2-naphthol to chiral 1,1′-Bi-2-naphthol (BINOL) achieved in good yield and ee were discussed.

Although many compounds look similar to this compound(119707-74-3)Electric Literature of C20H12Br2O2, numerous studies have shown that this compound(SMILES:OC1=C(Br)C=C2C=CC=CC2=C1C3=C4C=CC=CC4=CC(Br)=C3O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene, is researched, Molecular C31H26FeNOP, CAS is 291536-01-1, about Catalytic Enantioselective Formal Synthesis of MDM2 Antagonist RG7388 and Its Analogues, the main research direction is arylimino acetate enantioselective diastereoselective dipolar cycloaddition cyanostilbene copper catalyst; cyano triaryl pyrrolidine carboxylate asym synthesis; MDM2 antagonist RG7388 formal synthesis.Name: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene.

The catalytic asym. 1,3-dipolar [3 + 2] cycloaddition of azomethine ylides, generated in-situ from imino esters ArCH:NCH2CO2Me (Ar = 4-ClC6H4, 4-BrC6H4, 4-MeC6H4, 2-thienyl, 2-naphthyl), with cyanostilbenes R1C(CN):CHR2 (R1 = Ph, 4-ClC6H4; R2 = Ph, 4-MeC6H4, 3-BrC6H4, etc.) was established, affording structurally diverse pyrrolidines I (and their enantiomers) bearing four contiguous stereocenters with stereo-diversity in generally high yields and good to excellent stereoselectivities (up to 98% yield, 99:1 dr, >99% ee). This strategy allowed the formal synthesis of antitumor drug RG7388 (phase III clin. study) and its analogs in high efficiency.

Although many compounds look similar to this compound(291536-01-1)Name: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene, numerous studies have shown that this compound(SMILES:[H]C12=C3([H])[Fe+2]145678(C3=C94C%10=N[C@H](C%11=CC=CC=C%11)CO%10)([C-]%12C5=C6C7=C8%12)[C-]92P(C%13=CC=CC=C%13)C%14=CC=CC=C%14), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Investigation of the molecular characteristics of bisindole inhibitors as HIV-1 glycoprotein-41 fusion inhibitors.Computed Properties of C9H8BrN.

In previous work, we described 6-6′-bisindole compounds targeting a hydrophobic pocket on the N-heptad repeat region of viral glycoprotein-41 as effective inhibitors of HIV-1 fusion. Two promising compounds with sub-micromolar IC50’s contained a benzoic acid group and a benzoic acid ester attached at the two indole nitrogens. Here we have conducted a thorough structure-activity relationship (SAR) study evaluating the contribution of each of the ring systems and various substituents to compound potency. Hydrophobicity, polarity and charge were varied to produce 35 new compounds that were evaluated in binding, cell-cell fusion and viral infectivity assays. We found that (a) activity based solely on increasing hydrophobic content plateaued at ∼ 200 nM; (b) the bisindole scaffold surpassed other heterocyclic ring systems in efficacy; (c) a polar interaction possibly involving Gln575 in the pocket could supplant less specific hydrophobic interactions; and (d) the benzoic acid ester moiety did not appear to form specific contacts with the pocket. The importance of this hydrophobic group to compound potency suggests a mechanism whereby it might interact with a tertiary component during fusion, such as membrane. A promising small mol. 10b with sub-μM activity was discovered with mol. weight <500 da and reduced logP compared to earlier compounds The work provides insight into requirements for small mol. inhibition of HIV-1 fusion. Although many compounds look similar to this compound(1219741-50-0)Computed Properties of C9H8BrN, numerous studies have shown that this compound(SMILES:CC1=CNC2=C1C=CC(Br)=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary