Month: September 2022

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Quality Control of 2576-47-8.

Barravecchia, Liliana;Neira, Iago;Pazos, Elena;Peinador, Carlos;Garcia, Marcos D. research published 《 Amino acid-viologen hybrids: Synthesis, cucurbituril host-guest chemistry, and implementation on the production of peptides》, the research content is summarized as follows. We present herein the development of a series of viologen-amino acid hybrids, obtained in good yields either by successive alkylations of 4,4′-bipyridine, or by Zincke reactions followed by a second alkylation step. The potential of the obtained amino acids has been exemplified, either as typical guests of the cucurbituril family of hosts (particularly CB[7]/[8]) or as suitable building blocks for the solution/solid-phase synthesis of two model tripeptides with the viologen core inserted within their sequences.

Quality Control of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 19111-87-6, formula is C18H11Br, Name is 2-Bromotriphenylene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Computed Properties of 19111-87-6.

Barker, C. C.;Emmerson, R. G.;Periam, J. D. research published 《 Monosubstitution of triphenylene》, the research content is summarized as follows. The orientations of the products obtained by mononitration and by monobromination of triphenylene (I) were established, and the results discussed in the light of the predicted reactivity of I. 2-(1-Cyclohexen-1-yl)-1-(p-methoxyphenyl)cyclohexan-1-o1 (6 g.) and 4.6 g. monoperphthalic acid kept 16 hrs. at 0° in Et₂O gave 6.3 g. liquid, this liquid refluxed 24 hrs. with 44 cc. 34% HBr and 63 cc. AcOH, solution diluted with H₂O, and extracted with C₆H₆ gave 5.4 g. of residue. The residue heated 4 hrs. at 300° with Pd-C under N and the product sublimed at 200-20°/10^-2 mm., the sublimate extracted with KOH solution, and acidified gave 2-hydroxytriphenylene (II), m. 215-17° (from PhCl). I gave Na triphenylene-2-sulfonate (III) in 70% yield and III was converted into 72% crude II. Sublimation and crystallization gave 27% II based on III; picrate, m. 224-5° (decomposition); Me ether, m. 119° (from light petroleum); acetyl derivative, m. 130°. Refluxing an aqueous suspension of triphenylene-2-diazonium chloride, followed by sublimation and crystallization gave II isolated as the picrate. I (5 g.) in 40 cc. PhNO₂ containing 3.5 g. AlCl₃ mixed at 0° with 1.75 cc. AcCl, left 20 hrs. at room temperature, and 4 hrs. at 40° gave 5.25 g. 2-acetyltriphenylene (IV), m. 152-3° (from EtOH). IV (10 g.) in dioxane oxidized 1 hr. at 60° with 24 g. Br in 180 cc. H₂O containing 24 g. NaOH gave 8.3 g. triphenylene-2-carboxylic acid (V), m. 336-8° (from C₅H₁₁OH); Me ester, m. 171-2°; acid chloride (90% yield), m. 130-1°; amide (VI), m. 292-3° (from C₅H₅N); azide (VII), m. 135°. VII and PhCH₂OH gave benzyl N-(2-triphenylenyl)carbamate, m. 169-70°, which failed to give 2-aminotriphenylene (VIII) when heated at 140° with AcOH and concentrated HCl. Nitric acid (70%, 167 cc.) added 45 min. to 6 g. I in Ac₂O at 60°, the mixture kept at 60° for 4 hrs. and the product chromatographed on Al₂O₃ yielded 0.23 g. unchanged I, 1.96 g. 1-nitrotriphenylene (IX), m. 168.5-9.5°, and 1.63 g. 2-nitrotriphenylene, m. 165.5-6.0°. VII (3.5 g.), 100 cc. concentrated HCl, and 100 cc. AcOH refluxed 7 hrs. and the precipitate sublimed at 170-80°/10^-2 mm. gave 1.74 g. VIII, m. 140.0-0.5° (from EtOH); N-acetyl derivative, m. 257-8°. VI (0.9 g.) in MeOH containing 0.4 g. NaOEt treated 15 min. at 50° with 0.3 g. Br gave 0.35 g. Me N-(2-triphenylenyl)-carbamate (X), m. 188-9°. X (0.4 g.) refluxed 24 hrs. with 20 cc. concentrated HCl and AcOH gave 0.07 g. VIII. HCl passed for 2.5 hrs. into a refluxing mixture of AcOH and concentrated HCl containing 3.5 g. granulated Sn and 1.96 g. IX yielded 0.94 g. 1-aminotriphenylene, m. 103-4° (from EtOH). VIII (0.25 g.) in AcOH poured into 20% HBr to precipitate the amine-HBr salt which was diazotized at 0° with NaNO₂ in H₂O, the diazonium salt refluxed 0.5 hr. with 1.2 g. CuBr in 6 cc. 40% HBr, and the product sublimed at 160-80°/10^-2 mm. gave 0.1 g. 2-bromotriphenylene (XI), m. 131-2°. I (2 g.) in CCl₄ containing 0.09 g. Fe powder treated 72 hrs. at 20° with 1.4 g. Br and the crude product chromatographed on Al₂O₃ gave 1.49 g. XI. No 1-bromotriphenylene could be isolated. If present at all, then it would have to be formed in much smaller amounts than XI.

Computed Properties of 19111-87-6, 2-Bromotriphenylene is a useful research compound. Its molecular formula is C18H11Br and its molecular weight is 307.2 g/mol. The purity is usually 95%.
2-Bromotriphenylene is a brominating agent that has the ability to react with sodium carbonate and emit light. The luminescence of 2-bromotriphenylene can be used as an indicator of the degree of dilution, or how much water is present in a solution. It also emits light when it reacts with chloride ions in a reaction solution. 2-Bromotriphenylene can be used as a polymer matrix to form polymeric films, which are then used as catalysts for organic reactions. The luminescence properties of 2-bromotriphenylene make it suitable for use in functional theory experiments. This chemical compound is relatively low cost, and has been shown to have high yield in catalysis., 19111-87-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Category: bromides-buliding-blocks.

Bao, Qiao-Fei;Li, Ming;Xia, Yu;Wang, Yu-Zhao;Zhou, Zhao-Zhao;Liang, Yong-Min research published 《 Visible-Light-Mediated Decarboxylative Radical Addition Bifunctionalization Cascade for the Production of 1,4-Amino Alcohols》, the research content is summarized as follows. A photocatalytic decarboxylative radical addition bifunctionalization cascade for the synthesis of functionalized alcs. e.g., 2-(cyclohexylmethyl)-2-methylpent-4-enoic acid is described. The catalytic cycle is completed through single-electron transfer. The advantages of this reaction are the com. available materials, wide functional group compatibility, and mild conditions. Notably, some amino acids and bioactive carboxylic acids e.g., gemfibrozil can provide corresponding products e.g., 7-(2,5-dimethylphenoxy)-4,4-dimethyl-1,2,2-triphenylheptan-1-ol in moderate to good yields, reflecting the potential value in drug development.

Category: bromides-buliding-blocks, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde, Safety of 2-Bromo-4,5-dimethoxybenzaldehyde

Bao, Qiao-Fei;Xia, Yu;Li, Ming;Wang, Yu-Zhao;Liang, Yong-Min research published 《 Visible-Light-Mediated Trifluoromethylation/Benzylation of Styrenes Catalyzed by 4-CzIPN》, the research content is summarized as follows. Difunctionalization of alkenes is a valuable tool for the synthesis of complicated compounds from simple precursors. Herein, a feasible method for the construction of β-trifluoromethyl-α-substituted alcs. under visible-light-induced metal-free conditions is described. This catalytic system exhibits mild reaction conditions and good compatibility of functional groups. Trifluoromethyl and alcs. are valuable structural motifs due to their unique biol. properties, and this work shows the potential application in the realm of pharmacy and organic synthesis.

Safety of 2-Bromo-4,5-dimethoxybenzaldehyde, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide, Synthetic Route of 2576-47-8

Bao, Chenglong;Jiang, Yichen;Zhao, Liyan;Li, Dazhi;Xu, Ping;Sun, Jianmin research published 《 Aminoethylimidazole ionic liquid-grafted MIL-101-NH₂ heterogeneous catalyst for the conversion of CO₂ and epoxide without solvent and cocatalyst》, the research content is summarized as follows. Besides the activation of CO₂ by Lewis basic groups, the synergistic effects of Lewis acid sites (or hydrogen bond donor) together with halogen nucleophilic anions to activate epoxide ring opening were also important steps to develop an efficient catalyst for the cycloaddition reaction of CO₂ and epoxides. Herein, an aminoethylimidazole IL-modified MOF catalyst with multiple catalytic active sites (denoted as MIL-101-NHIM-NH₂) was synthesized through an aldimine condensation post-synthesis method. Through thorough characterizations, such as FT-IR, XRD, SEM-EDS mappings, N₂ adsorption and desorption, XPS, elemental anal. and TG measurement, the results showed that the surface of MIL-101-NHIM-NH₂ was successfully grafted with the ionic liquid Owing to the synergistic effects of multiple active sites containing Cr, -NH₂ and Br- in the MIL-101-NHIM-NH₂ catalyst, MIL-101-NHIM-NH₂ could efficiently catalyze the cycloaddition reaction of CO₂ and epoxide without addnl. solvent and cocatalyst; 93.5% of propylene carbonate was obtained at 120°C, 2 MPa and 4 h. Moreover, MIL-101-NHIM-NH₂ also showed better recycling stability within five catalytic runs and easy separation in the CO₂ cycloaddition reaction.

2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., Synthetic Route of 2576-47-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., COA of Formula: C9H9BrO3.

Banik, Trisha;Kaliappan, Krishna P. research published 《 A Serendipitous One-Pot Cyanation/Hydrolysis/Enamide Formation: Direct Access to 3-Methyleneisoindolin-1-ones》, the research content is summarized as follows. A direct, one-pot conversion of 2′-haloacetophenones 2-X-3-R-4-R¹-5-R²C₆HC(O)CHR³(R⁴) (X = Br, I; R = H, azanyl, Ph, etc.; R¹ = H, OMe; R² = H, F, dibenzylaminyl, etc.; R³ = H, Ph, n-Hex, etc.; R⁴ = H, Me; R¹R² = -OCH₂O- and 1-(2-bromopyridin-3-yl)ethanone) to 3-methyleneisoindolin-1-ones I and 5-methylene-5H-pyrrolo[3,4-b]pyridin-7(6H)-one scaffold using CuCN as the sole reagent without the need for moisture-free or anaerobic conditions is reported. This serendipitously discovered transformation with a broad substrate scope provides a significantly different route towards these important scaffolds. The scope of the method has also been further extended towards the synthesis of three special scaffolds, which are analogous to various bio-active drugs.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., COA of Formula: C9H9BrO3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Quality Control of 585-76-2.

Bal, Ankita;Kumar Dinda, Tarun;Mal, Prasenjit research published 《 Mechanochemical Aliphatic Iodination (and Bromination) by Cascaded Cyclization》, the research content is summarized as follows. Herein, the synthesis of oxazoline derivatives I [Ar = Ph, 4-MeC₆H₄, 3-BrC₆H₄, etc.] from N-allyl benzamides via mechanochem. cascaded cyclization and halogenation using N-iodo- and N-bromosuccinimides, resp., as bifunctional reagents was demonstrated.

585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , Quality Control of 585-76-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Organic compounds having carbon bonded to bromine are called organic bromides. Recommanded Product: 3,5-Dibromo-2-hydroxybenzaldehyde.

Bakthadoss, Manickam;Mushaf, Mohammad;Agarwal, Vishal;Reddy, Tadiparthi Thirupathi;Sharada, Duddu S. research published 《 Azomethine ylide cycloaddition of 1,3-dienyl esters: highly regio- and diastereoselective synthesis of functionalized pyrrolidinochromenes》, the research content is summarized as follows. An efficient protocol for the synthesis of tricyclic pyrrolidinochromenes I [R = H, 6-OEt, 6,8-Cl₂, etc. ; R¹ = Me, Et, Bu; R² = Me, Et; R³ = H, Me] was developed via an intramol. 1,3-dipolar cycloaddition of azomethine ylides generated in situ from 1,3-dienyl ester tethered O-hydroxyarylaldehyde and glycine esters. The reaction was highly regio- and diastereoselective in nature and provided the potentially bioactive pyrrolidine fused tricyclic cycloadducts in excellent yields with wide substrate scope. Interestingly this reaction constructed two rings and four contiguous stereogenic centers in which one of them was an all carbon quaternary center in a unique fashion.

Recommanded Product: 3,5-Dibromo-2-hydroxybenzaldehyde, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., 90-59-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane, SDS of cas: 629-04-9

Bakthadoss, Manickam;Agarwal, Vishal;Tadiparthi, Thirupathi Reddy;Mohammad, Mushaf research published 《 Domino ring opening and selective O/S-alkylation of cyclic ethers and thioethers》, the research content is summarized as follows. Chemoselective domino ring opening and selective O/S-alkylation of ethers/thioethers over enol C/O alkylation has been observed Various 2-aryl chromanones/thiochromanones with alkyl/allyl bromides were smoothly converted into the corresponding highly functionalized ethers and thioethers in excellent yields with high selectivity.

SDS of cas: 629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Recommanded Product: 6-Bromohexanoic acid.

Bai, Yulong;Wan, Wang;Huang, Yanan;Jin, Wenhan;Lyu, Haochen;Xia, Qiuxuan;Dong, Xuepeng;Gao, Zhenming;Liu, Yu research published 《 Quantitative interrogation of protein co-aggregation using multi-color fluorogenic protein aggregation sensors》, the research content is summarized as follows. Co-aggregation of multiple pathogenic proteins is common in neurodegenerative diseases but deconvolution of such biochem. process is challenging. Herein, we developed a dual-color fluorogenic thermal shift assay to simultaneously report on the aggregation of two different proteins and quant. study their thermodn. stability during co-aggregation. Expansion of spectral coverage was first achieved by developing multi-color fluorogenic protein aggregation sensors. Orthogonal detection was enabled by conjugating sensors of minimal fluorescence crosstalk to two different proteins via sortase-tag technol. Using this assay, we quantified shifts in melting temperatures in a heterozygous model protein system, revealing that the thermodn. stability of wild-type proteins was significantly compromised by the mutant ones but not vice versa. We also examined how small mol. ligands selectively and differentially interfere with such interplay. Finally, we demonstrated these sensors are suited to visualize how different proteins exert influence on each other upon their co-aggregation in live cells.

Recommanded Product: 6-Bromohexanoic acid, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary