Month: September 2022

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 19111-87-6, formula is C18H11Br, Name is 2-Bromotriphenylene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Name: 2-Bromotriphenylene.

Astier, Raymond;Meyer, Yves research published 《 Transitory absorption bands between 5000 and 8800 A. in aromatic and heterocyclic molecules》, the research content is summarized as follows. Transitory absorption spectra attributable to triplet-triplet transitions were obtained at 3000-8800 A. by a brief, intense light excitation of anthracene, triphenylene, 2-bromotriphenylene, quinoxaline, and anthraquinone in alc. (EtOH:MeOH, 3:1) solution at 113°K. All these mols. had transitory absorption bands in the red part of the spectrum. Intense optical pumping with Xe flash tubes combined with low temperatures gave a large proportion of mols. in a metastable state with a life of a few msec. With anthracene, a triplet state population >95% was measured. The regions of absorption S* ← S(A), fluorescence (F), and phosphorescence T → S(P) are indicated in a figure.

Name: 2-Bromotriphenylene, 2-Bromotriphenylene is a useful research compound. Its molecular formula is C18H11Br and its molecular weight is 307.2 g/mol. The purity is usually 95%.
2-Bromotriphenylene is a brominating agent that has the ability to react with sodium carbonate and emit light. The luminescence of 2-bromotriphenylene can be used as an indicator of the degree of dilution, or how much water is present in a solution. It also emits light when it reacts with chloride ions in a reaction solution. 2-Bromotriphenylene can be used as a polymer matrix to form polymeric films, which are then used as catalysts for organic reactions. The luminescence properties of 2-bromotriphenylene make it suitable for use in functional theory experiments. This chemical compound is relatively low cost, and has been shown to have high yield in catalysis., 19111-87-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Name: 2-Bromo-4,5-dimethoxybenzaldehyde.

Asressu, Kesatebrhan Haile;Chan, Chieh-Kai;Wang, Cheng-Chung research published 《 TMSOTf-catalyzed synthesis of trisubstituted imidazoles using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions》, the research content is summarized as follows. A TMSOTf-catalyzed synthesis of trisubstituted imidazoles through the reaction of 1,2-diketones and aldehydes using hexamethyldisilazane as a nitrogen source under microwave heating and solvent-free conditions was developed. The chem. structures of representative trisubstituted imidazoles were confirmed using X-ray single-crystal diffraction anal. This synthetic method had several advantages including the involvement of mild Lewis acid, being metal- and additive-free, wide substrate scope with good to excellent yields and short reaction time. Furthermore, the application of the methodol. was demonstrated in the synthesis of biol. active imidazole-based drugs.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Name: 2-Bromo-4,5-dimethoxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Application of C7H4Br2O2.

Ashfaq, Muhammad;Ali, Akbar;Nawaz Tahir, Muhammad;Khalid, Muhammad;Assiri, Mohammed A.;Imran, Muhammad;Shahzad Munawar, Khurram;Habiba, Ume research published 《 Synthetic approach to achieve halo imine units: Solid-state assembly, DFT based electronic and non linear optical behavior》, the research content is summarized as follows. Herein, two crystalline schiff bases: (E)-2,4-dibromo-6-(((3,4-dichlorophenyl)imino)methyl)phenol (DCBA) and (E)-2,4-dichloro-6-(((2,4,5-trichlorophenyl)imino)methyl)phenol(TCCA) were prepared by treating halo-substituted benzaldehydes with chloro-substituted aniline through condensation reaction. The crystal structures of DCBA and TCCA were confirmed by SC-XRD anal., which unambiguously revealed that C-H···Br, C-Cl···π, and off-set π···π stacking interactions were the key aspects of crystal packing of DCBA, whereas π···π off-set stacking interactions were the main aspect of crystal packing of TCCA. Hirshfeld surface anal. had been implemented for the further probe of intermol. interactions. Accompanying with exptl., DFT investigation had also been performed at M06/6-311G(d,p) level to analyze these crystalline architectures. By comparative anal. of geometrical parameters, an efficient agreement was observed between DFT and SC-XRD data. Addnl., natural bond orbital (NBO) findings revealed that most dominant hyper-conjugative transitions with higher stability (31.06 and 30.70 kcal/mol) had been examined for DCBA and TCCA, resp., which may cause the stability of these mols. Further, global reactivity parameters disclosed that both compounds showed larger value of hardness (η = 2.181-2.205 eV) with least value of softness (σ = 0.226-0.229 eV) which indicated them kinetically enormous stable and show excellent concurrence with NBO and SC-XRD. The band gaps of DCBA and TCCA had been rationalized to be 4.40 and 4.36 eV, resp. Interestingly, significant values of dipole moment [μ_total = 1.03 and 4.16 a.u.], linear polarizability [<α>=309 and 1167.51 a.u.] and second order hyperpolarizability [<γ> =3.90-4.18 x 10⁵a.u.] were investigated in the entitled compounds Remarkable NLO response of aforesaid compounds designated them as outstanding NLO materials for the hi-tech optoelectronic applications.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Application of C7H4Br2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Reference of 823-78-9.

Asgari, Mohammad S.;Tahmasebi, Behnam;Mojtabavi, Somayeh;Faramarzi, Mohammad A.;Rahimi, Rahmatollah;Ranjbar, Parviz R.;Biglar, Mahmood;Larijani, Bagher;Rastegar, Hossein;Mohammadi-Khanaposhtani, Maryam;Mahdavi, Mohammad research published 《 Design, synthesis, biological evaluation, and docking study of new acridine-9-carboxamide linked to 1,2,3-triazole derivatives as antidiabetic agents targeting α-glucosidase》, the research content is summarized as follows. A new series of acridine-9-carboxamide-1,2,3-triazole derivatives I [R = H, 2-Me, 4-O₂N, etc.] were designed, synthesized and evaluated as novel α-glucosidase inhibitors. Compounds I were designed by combination of effective moieties from potent α-glucosidase inhibitors. Most of the synthesized compounds I were more potent than standard inhibitor acarbose. Among the synthesized compounds, the most potent compounds were I [R = 3-Br, 4-Br, H] with IC₅₀ values of 120.2 ± 1.0, 151.1 ± 1.4, and 157.6 ± 1.6μM, resp. (IC₅₀ value of acarbose = 750.0 ± 10.0μM). Docking study of the most potent compounds I [R = H, 3-Br, 4-Br] reported that these compounds formed stable complexes with α-glucosidase active site. Anti-α-amylase assay of compounds I [R = H, 3-Br, 4-Br] was performed and no activity was observed, meanwhile in-vitro cytotoxicity assay of the latter compounds revealed that these compounds were not cytotoxic toward human normal (HDF) and cancer (MCF-7) cell lines. ADME and toxicity prediction of compounds I [R = H, 3-Br, 4-Br] were also performed.

Reference of 823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., 823-78-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 823-78-9, formula is C7H6Br2, The most pervasive is the naturally produced bromomethane. Safety of 1-Bromo-3-(bromomethyl)benzene

Asgari, Mohammad S.;Azizian, Homa;Nazari Montazer, Mohammad;Mohammadi-Khanaposhtani, Maryam;Asadi, Mehdi;Sepehri, Saghi;Ranjbar, Parviz R.;Rahimi, Rahmatollah;Biglar, Mahmood;Larijani, Bagher;Amanlou, Massoud;Mahdavi, Mohammad research published 《 New 1,2,3-triazole-(thio)barbituric acid hybrids as urease inhibitors: Design, synthesis, in vitro urease inhibition, docking study, and molecular dynamic simulation》, the research content is summarized as follows. A new series of 1,2,3-triazole-(thio)barbituric acid hybrids 8a-n was designed and synthesized on the basis of potent pharmacophores with urease inhibitory activity. Therefore, these compounds were evaluated against Helicobacter pylori urease. The obtained result demonstrated that all the synthesized compounds, 8a-n, were more potent than the standard urease inhibitor, hydroxyurea. Moreover, among them, compounds 8a, 8c-e, 8g,h, and 8k,l exhibited higher urease inhibitory activities than the other standard inhibitor used: thiourea. Docking studies were performed with the synthesized compounds Furthermore, mol. dynamic simulation of the most potent compounds, 8e and 8l, showed that these compounds interacted with the conserved residues Cys592 and His593, which belong to the active site flap and are essential for enzymic activity. These interactions have two consequences: (a) blocking the movement of a flap at the entrance of the active site channel and (b) stabilizing the closed active site flap conformation, which significantly reduces the catalytic activity of urease. Calculation of the physicochem. and topol. properties of the synthesized compounds 8a-n predicted that all these compounds can be orally active. The ADME prediction of compounds 8a-n was also performed.

823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., Safety of 1-Bromo-3-(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Reference of 4897-84-1.

Asano, Shota;Itto-Nakama, Kaori;Arimoto, Hirokazu research published 《 Carbamate as an accelerating group in intermolecular Pauson-Khand reaction》, the research content is summarized as follows. The Pauson-Khand reaction (PKR) is a powerful means for the construction of cyclopentenones. However, its applications are limited to the intramol. version of this reaction because poor yield and regioselectivity are often the major problems in intermol. PKR. Herein, it was shown that a carbamate moiety in alkene substrate accelerates this intermol. PKR. The reaction of N-4-dimethylaminophenyl O-allyl carbamate with alkyne-cobalt complex gave cyclopentenones in high yields (up to 90%) and regioselectivity (>9:1).

Reference of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Synthetic Route of 823-78-9.

Asadizadeh, Saeedeh;Sohrabi, Marzieh;Mereiter, Kurt;Farrokhpour, Hossein;Meghdadi, Soraia;Amirnasr, Mehdi research published 《 Novel octanuclear copper(I) clusters [Cu₈{(N)-(μ₄-S)}₄(μ₃-I)₂I₂(PPh₃)₂] produced via reductive S-S bond cleavage of disulfide Schiff base ligands and their use as efficient heterogeneous catalysts in CuAAC click reaction》, the research content is summarized as follows. Herein, the facile one pot synthesis of novel octanuclear copper(I) complexes, [Cu₈{(N)-(μ₄-S)}₄(μ₃-I)₂I₂(PPh₃)₂], by the reaction of copper(I) iodide and disulfide Schiff base mols. (R-CH=NPhSSPh-N=CH-R, RMePh = 4-MePh, RMeOPh = 4-MeOPh, RMeSPh = 4-MeSPh, RBrPh = 4-BrPh, and RFur = 2-furan) in the presence of PPh₃ in dichloromethane-acetonitrile or chloroform-acetonitrile solution under ambient conditions is reported. Single-crystal X-ray structure analyses of these clusters confirm the presence of Cu₈S₄I₄ core stabilized by the chelating Schiff base thiolate fragment R-CH=N-Ph-S^– produced by the reductive cleavage of disulfide bond, I^–, and PPh₃. DFT calculations have been performed to describe a speculative mechanism of cluster formation. The octanuclear clusters [Cu₈{(N)-(μ₄-S)}₄(μ₃-I)₂I₂(PPh₃)₂] have been exploited as efficient heterogeneous catalysts for the green synthesis of 1,2,3-triazoles from NaN₃, alkyl halides, and alkyne derivatives (CuAAC reaction) under mild conditions.

823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., Synthetic Route of 823-78-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organic compounds having carbon bonded to bromine are called organic bromides. Recommanded Product: 3-Bromobenzoic acid.

Aravindan, Narasingan;Vinayagam, Varathan;Jeganmohan, Masilamani research published 《 A Ruthenium-Catalyzed Cyclization to Dihydrobenzo[c]phenanthridinone from 7-Azabenzonorbornadienes with Aryl Amides》, the research content is summarized as follows. An efficient ruthenium(II)-catalyzed tandem C-C/C-N bond formation with aryl amides and 7-azabenzonorbornadienes was developed to synthesize cis-fused dihydrobenzo[c]phenanthridinones. The amide group functions as a directing group as well as a leaving group and provided an easy access to the pharmaceutically useful benzo[c]phenanthridine alkaloids such as nitidine and fagaronine analogs. The present methodol. was compatible with various functional groups with respect to azabicyclic alkenes and aromatic amides. The reaction mechanism involving directing-group-assisted C-H activation was proposed and supported by the deuterium labeling studies.

Recommanded Product: 3-Bromobenzoic acid, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 5445-17-0, formula is C4H7BrO2, The most pervasive is the naturally produced bromomethane. Product Details of C4H7BrO2

Antien, Kevin;Geraci, Andrea;Parmentier, Michael;Baudoin, Olivier research published 《 A New Dioxazolone for the Synthesis of 1,2-Aminoalcohols via Iridium(III)-Catalyzed C(sp³)-H Amidation》, the research content is summarized as follows. Vicinal aminoalcs. are widespread structural motifs in bioactive mols. The development of a new dioxazolone reagent containing a p-nitrophenyldifluoromethyl group, which 1. displays a good safety profile; 2. shows a remarkably high reactivity in the oxime-directed iridium(III)-catalyzed amidation of unactivated C(sp³)-H bonds; 3. leads to amide products which can be hydrolyzed under mild conditions has been reported. The amidation reaction is mild, general and compatible with both primary C-H bonds of tertiary and secondary alcs., as well as secondary C-H bonds of cyclic secondary alcs. This method provides an easy access to free 1,2-aminoalcs. after efficient and mild cleavage of the oxime directing group and activated amide.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Product Details of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary