Month: September 2022

Al Enezy-Ulbrich, Miriam Aischa team published research on Advanced Functional Materials in 2020 | 5445-17-0

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Electric Literature of 5445-17-0

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Electric Literature of 5445-17-0.

Al Enezy-Ulbrich, Miriam Aischa;Malyaran, Hanna;de Lange, Robert Dirk;Labude, Norina;Plum, Rene;Ruetten, Stephan;Terefenko, Nicole;Wein, Svenja;Neuss, Sabine;Pich, Andrij research published 《 Impact of Reactive Amphiphilic Copolymers on Mechanical Properties and Cell Responses of Fibrin-Based Hydrogels》, the research content is summarized as follows. Mech. properties of hydrogels can be modified by the variation of structure and concentration of reactive building blocks. One promising biol. source for the synthesis of biocompatible hydrogels is fibrinogen. Fibrinogen is a glycoprotein in blood, which can be transformed enzymically to fibrin playing an important role in wound healing and clot formation. In the present work, it is demonstrated that hybrid hydrogels with their improved mech. properties, tunable internal structure, and enhanced resistance to degradation can be synthesized by a combination of fibrinogen and reactive amphiphilic copolymers. Water-soluble amphiphilic copolymers with tunable mol. weight and controlled amounts of reactive epoxy side groups are used as reactive crosslinkers to reinforce fibrin hydrogels. In the present work, copolymers that can influence the mech. properties of fibrin-based hydrogels are used. The reactive copolymers increase the storage modulus of the hydrogels from 600 Pa to 30 kPa. The thickness of fibrin fibers is regulated by the copolymer concentration It could be demonstrated that the fibrin-based hydrogels are biocompatible and support cell proliferation. Their degradation rate is considerably slower than that of native fibrin gels. In conclusion, fibrin-based hydrogels with tunable elasticity and fiber thickness useful to direct cell responses like proliferation and differentiation are produced.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Electric Literature of 5445-17-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cas: 611-75-6 was involved in experiment | European Journal of Organic Chemistry 2014

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) (BHH; 250μM; 24 hours) also significantly attenuates HGF-induced invasion of LNCaP and C4-2B cells that natively express TMPRSS2. No significant toxicity is observed over a 48-hour period exposing LNCaP, DU145, PC3, or HepG2 cells to Bromhexine hydrochloride concentrations ranging from 0μM to 250μM. Bromhexine hydrochloride exposure does not induce cell death or substantially suppress the growth of DU145 cells.Bromhexine hydrochloride (20 μM; 48 h) inhibits dendritic cells infection with HIV-1.HPLC of Formula: 611-75-6

Sharif, Muhammad;Pews-Davtyan, Anahit;Lukas, Jan;Schranck, Johannes;Langer, Peter;Rolfs, Arndt;Beller, Matthias published 《Palladium-Catalyzed Carbonylative Transformations of Bromhexine into Bioactive Compounds as Glucocerebrosidase Inhibitors》. The research results were published in《European Journal of Organic Chemistry》 in 2014.HPLC of Formula: 611-75-6 The article conveys some information:

A general synthesis for dicarbonylated derivatives of the parent drug bromhexine is described. By using com. available Pd(OAc)2/BuPAd2 [CataCXium A, Ad = adamantyl, (butyl)bis(tricyclo[3.3.1.13,7]dec-1-yl)phosphine] catalyst system, the carbonylative arylation, amination and alkoxylation of bromohexine proceeded with up to 79% product yield. Selected synthesized derivatives of bromhexine showed improved effects as glucocerebrosidase inhibitors. The synthesis of the target compounds was achieved using 2-amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethanamine (bromhexine) as a starting material. And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) (BHH; 250μM; 24 hours) also significantly attenuates HGF-induced invasion of LNCaP and C4-2B cells that natively express TMPRSS2. No significant toxicity is observed over a 48-hour period exposing LNCaP, DU145, PC3, or HepG2 cells to Bromhexine hydrochloride concentrations ranging from 0μM to 250μM. Bromhexine hydrochloride exposure does not induce cell death or substantially suppress the growth of DU145 cells.Bromhexine hydrochloride (20 μM; 48 h) inhibits dendritic cells infection with HIV-1.HPLC of Formula: 611-75-6

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Learn more about cas: 611-75-6 | International Journal for Pharmaceutical Research Scholars 2016

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Reference of 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride

Ayre, Anita Pandurang;Marathe, Deepak Subhash;Borkar, Shilpa published 《Formulation and evaluation of orodispersible films of bromhexine HCl-a patient friendly approach》 in 2016. The article was appeared in 《International Journal for Pharmaceutical Research Scholars》. They have made some progress in their research.Reference of 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride The article mentions the following:

The present investigation was carried out with the objective of formulating orodispersible forms of the mucolytic drug, Bromhexine HCl to enhance convenience and compliance to the elderly and pediatric patients for better therapeutic efficacy. Orodispersible films of Bromhexine HCl were prepared by solvent evaporation technique. Formulation studies were carried out using different polymer combinations, the obtained films were evaluated for their appearance, color, elegance, continuity, texture, presence of air bubbles, stickiness to Petri dish, cracks, cuttings, and imperfections. Alginate and HPMC based films recorded the fastest disintegration when used alone and in mixtures with PVP-K25 and maltodextrin. Xanthan gum film had the longest disintegration time. Moreover, adding xanthan gum, Na CMC, and carbopol prolonged the disintegration time of HPMC and alginate films. A good correlation existed between the calculated dissolution rate of each film and its disintegration time. Formulas F1and F7 showed the highest resistance against moisture absorption and recoded tensile strength values of 15.47 and 17.16 kg/mm2, resp. after storage. Films based on HPMC alone or in combination with other polymers exhibited high resistance against moisture absorption except with Na CMC. Alginate and xanthan gum based films had a higher affinity for moisture absorption. The addition of maltodextrin significantly decreased the percentage moisture absorption after storage at 97% relative humidity. This effect was concentration-dependent. Thus disintegration time of film was 25 s, drug content 92.4 % and drug release was 96.3 %. The developed formulation was found to be stable under the conditions tested. To complete the study, the researchers used 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Reference of 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Xiaotong et al. published new experimental results with the assistance of cas: 611-75-6

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. Category: bromides-buliding-blocks

Wang, Xiaotong;Li, Linghui;Ran, Xiaoku;Dou, Deqiang;Li, Bin;Yang, Bingyou;Li, Wei;Koike, Kazuo;Kuang, Haixue published 《What caused the changes in the usage of Atractylodis Macrocephalae Rhizoma from ancient to current times?》. The research results were published in《Journal of Natural Medicines》 in 2016.Category: bromides-buliding-blocks The article conveys some information:

Ancient Chinese medicine treatises on Atractylodis Macrocephalae Rhizoma (AMR), the rhizome of Atractylodes macrocephala Koidz, indicated that it possessed an expectorant effect. However, in modern times, it is commonly used as a tocolytic agent. In this study, the components of AMR that are responsible for its expectorant and tocolytic effects were evaluated in order to clarify the differences in its application between ancient and modern times. A decoction of AMR was separated into five fractions, namely, volatile oil (VO), petroleum ether (PE), alc. eluate from macroporous resin (AE), water eluate from macroporous resin (WE), and polysaccharides (PS), using various separation methods. The expectorant experiment indicated that the VO fraction, which mainly contains atractylone, produced an obvious expectorant effect. The experiment that assessed the irritability of uterine smooth muscle (USM) showed that the PE, which is mainly composed of atractylenolides, and the PS, which is mainly composed of inulin-type polysaccharides, were the active fractions for tocolysis, but the VO fraction had the opposite action. These data suggested that volatile oils are the key components responsible for the usage change of AMR in both ancient and current usage. The experimental procedure involved many compounds, such as 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. Category: bromides-buliding-blocks

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Explore more uses of cas: 611-75-6 | Zhongguo Yaoshi (Beijing, China)

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. COA of Formula: C14H21Br2ClN2

COA of Formula: C14H21Br2ClN2In 2016, Li, Wendong;Wang, Chenggang;Wu, Kechun;Liu, Haitao;Wang, Junqiu published 《Comparative study on domestic bromhexine hydrochloride tablets and primary research preparation》. 《Zhongguo Yaoshi (Beijing, China)》published the findings. The article contains the following contents:

Objective: To evaluate the quality of domestic bromhexine hydrochloride tablets and primary research preparations Methods: The dissolution curves of the tablets and preparation in four dissolution media were compared. The quality of Bromhexine Hydrochloride Tablets was analyzed with the new related substances method. Results: The comparative study showed the dissolution curve of one domestic manufacturer was similar to that of the original manufacturer. Impurity profiles anal. showed that unknown impurity X which came from API was the main reason to influence the purity level of domestic preparations, meanwhile, impurity X was not detected in primary research preparations Conclusion: The quality of API was the main factor to influence the quality of domestic preparations There was difference in manufacturing technique between foreign API and domestic API.2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) were involved in the experimental procedure.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. COA of Formula: C14H21Br2ClN2

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Learn more about cas: 611-75-6 | Journal of Chemical and Pharmaceutical Research 2015

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. HPLC of Formula: 611-75-6

Rele, Rajan V. published 《Simultaneous UV-spectrophotometric estimation of bromhexine hydrochloride and salbutamol sulphate by first order derivative method in combined dosage form》 in 2015. The article was appeared in 《Journal of Chemical and Pharmaceutical Research》. They have made some progress in their research.HPLC of Formula: 611-75-6 The article mentions the following:

The objective of the study was to develop a simple, accurate, precise and rapid UV spectrophotometric, first order derivative, method for simultaneous estimation of bromhexine hydrochloride and salbutamol sulfate from combined dosage form. The validation was carried out by using ICH guidelines for the determination of bromhexine hydrochloride and salbutamol sulfate by using 0.1N hydrochloric acid as the solvent in pharmaceutical dosage form. The proposed first order derivative method involves the measurement of absorbance of one drug at zero crossing point of other; hence wavelengths 240 nm and 233 nm were selected for the estimation of bromhexine hydrochloride and salbutamol sulfate resp. The linearity of the proposed method was found in the concentration range of 2 to 14 μg /mL (r2= 0.9995) for bromhexine hydrochloride and 2 to 16 μg /mL (r2 = 0.9996) for salbutamol sulfate resp. The percentage mean recovery was found to be 100.166 % for bromhexine hydrochloride and 100.147 % for salbutamol sulfate resp. The method was also statistically validated for its linearity, accuracy and precision. Both intra and inter day variations showed less percentage (%) RSD values indicating high grade of precision of this method. And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. HPLC of Formula: 611-75-6

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Learn more about cas: 611-75-6 | European Journal of Chemistry 2022

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. Category: bromides-buliding-blocks

Abdullatif, Hind Ali;Michael, Adel Magdy;Trabik, Yossra Ahmed;Ayad, Miriam Farid published 《Critical assessment of smart calculation-based spectroscopy versus chemometric-assisted methods: application to combined antibiotic formulations》. The research results were published in《European Journal of Chemistry》 in 2022.Category: bromides-buliding-blocks The article conveys some information:

This work describes a comparative study of two multivariate chemometric and univariate spectrophotometric methods for the determination of a ternary drug mixture containing oxytetracycline HCl, bromhexine HCl, and lidocaine HCl. All methods show high sensitivity and similar linearity range. Meanwhile, the chemometric method has the advantage of higher accuracy, higher specificity and better regression parameters. The two spectrophotometric methods are constant multiplication coupled with spectrum subtraction and successive ratio subtraction coupled with spectrum subtraction while the chemometric method used partial least square and principal component regression models. In addition, a spiking technique was used to increase the concentration of bromhexine HCl in the dosage form, allowing its determination despite its low contribution. Methods were successfully applied in the dosage form Oxyclear veterinary injection in pure powder as well as in its pharmaceutical formulation. Statistical comparison showed no significant difference between the developed methods and the reference method. And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. Category: bromides-buliding-blocks

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Learn more about cas: 611-75-6 | Yakhak Hoechi 2013

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Computed Properties of C14H21Br2ClN2

Computed Properties of C14H21Br2ClN2In 2013, Lee, Tae-Woong;Jeong, Rae-Seok;Jeong, Seung-A.;Kim, Jeong-Hyun;Shim, Young-Hun;Kim, In-Kyu;Park, Chang-Won published 《Development of dissolution test method for acebrophylline capsules and bromhexine hydrochloride tablets in Korean pharmaceutical codex》. 《Yakhak Hoechi》published the findings. The article contains the following contents:

Although the dissolution test can serve as an effective tool for quality control and predictor of in vivo performance, there are a number of drugs with no established dissolution specification in Korean Pharmaceutical Codex (KPC). So, with each reference and test drugs, the dissolution test method and an anal. procedure by HPLC were developed and validated to establish dissolution specification for acebrophylline capsules and bromhexine hydrochloride tablets. The dissolution condition was determined based on the “Guidelines on Specifications of Dissolution tests for Oral dosage forms” of Ministry of Food and Drug Safety (MFDS). The anal. method of HPLC was validated in specificity, linearity, precision and accuracy. Final dissolution test was performed with com. available samples of 3 lots to establish specification. In addition, no difference was observed by the inter-laboratory evaluation. Dissolution specifications and conditions will be used for revising the monograph of acebrophylline capsules and bromhexine hydrochloride tablets in next supplement of KPC. To complete the study, the researchers used 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Computed Properties of C14H21Br2ClN2

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

New progress of cas: 611-75-6 | BMJ [British Medical Journal] 2015

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Recommanded Product: 611-75-6

Ko, Tai-Ming;Tsai, Chang-Youh;Chen, Shih-Yang;Chen, Kuo-Shu;Yu, Kuang-Hui;Chu, Chih-Sheng;Huang, Chung-Ming;Wang, Chrong-Reen;Weng, Chia-Tse;Yu, Chia-Li;Hsieh, Song-Chou;Tsai, Jer-Chia;Lai, Wen-Ter;Tsai, Wen-Chan;Yin, Guang-Dar;Ou, Tsan-Teng;Cheng, Kai-Hung;Yen, Jeng-Hsien;Liou, Teh-Ling;Lin, Tsung-Hsien;Chen, Der-Yuan;Hsiao, Pi-Jung;Weng, Meng-Yu;Chen, Yi-Ming;Chen, Chen-Hung;Liu, Ming-Fei;Yen, Hsueh-Wei;Lee, Jia-Jung;Kuo, Mei-Chuan;Wu, Chen-Ching;Hung, Shih-Yuan;Luo, Shue-Fen;Yang, Ya-Hui;Chuang, Hui-Ping;Chou, Yi-Chun;Liao, Hung-Ting;Wang, Chia-Wen;Huang, Chun-Lin;Chang, Chia-Shuo;Lee, Ming-Ta Michael;Chen, Pei;Wong, Chih-Shung;Chen, Chien-Hsiun;Wu, Jer-Yuarn;Chen, Yuan-Tsong;Shen, Chen-Yang published 《Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study》 in 2015. The article was appeared in 《BMJ [British Medical Journal]》. They have made some progress in their research.Recommanded Product: 611-75-6 The article mentions the following:

Objective: To evaluate the use of prospective screening for the HLA-B*58:01 allele to identify Taiwanese individuals at risk of severe cutaneous adverse reactions (SCARs) induced by allopurinol treatment. Design: National prospective cohort study. Setting: 15 medical centers in different regions of Taiwan, from July 2009 to August 2014. Participants 2926 people who had an indication for allopurinol treatment but had not taken allopurinol previously. Participants: were excluded if they had undergone a bone marrow transplant, were not of Han Chinese descent, and had a history of allopurinol induced hypersensitivity. DNA purified from 2910 participants’ peripheral blood was used to assess the presence of HLA-B*58:01. Main Outcome Measures: Incidence of allopurinol induced SCARs with and without screening. Results: Participants who tested pos. for HLA-B*58:01 (19.6%, n = 571) were advised to avoid allopurinol, and were referred to an alternate drug treatment or advised to continue with their prestudy treatment. Participants who tested neg. (80.4%, n = 2339) were given allopurinol. Participants were interviewed once a week for two months to monitor symptoms. The historical incidence of allopurinol induced SCARs, estimated by the National Health Insurance research database of Taiwan, was used for comparison. Mild, transient rash without blisters developed in 97 (3%) participants during follow-up. None of the participants was admitted to hospital owing to adverse drug reactions. SCARs did not develop in any of the participants receiving allopurinol who screened neg. for HLA-B*58:01. By contrast, seven cases of SCARs were expected, based on the estimated historical incidence of allopurinol induced SCARs nationwide (0.30% per yr, 95% confidence interval 0.28% to 0.31%; P = 0.0026; two side one sample binomial test). Conclusions: Prospective screening of the HLA-B*58:01 allele, coupled with an alternative drug treatment for carriers, significantly decreased the incidence of allopurinol induced SCARs in Taiwanese medical centers. The experimental procedure involved many compounds, such as 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Recommanded Product: 611-75-6

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Kong, Dexian et al. published new progress in experiments with the help of cas: 611-75-6

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Quality Control of 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride

Kong, Dexian;Huang, Siqin;Cheng, Jiansong;Zhuang, Qizhao;Liu, Yijun;Lu, Chun-Hua published 《Sensitive determination of bromhexine hydrochloride based on its quenching effect on luminol/H2O2 electrochemiluminescence system》 in 2018. The article was appeared in 《Luminescence》. They have made some progress in their research.Quality Control of 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride The article mentions the following:

In this paper, the electrochemiluminescence (ECL) behavior of luminol/H2O2 system in the presence of bromhexine hydrochloride (BrH) was investigated. It was found that the ECL intensity of luminol/H2O2 system on a platinum electrode could be intensely quenched by BrH owing to the scavenging superoxide radical ability of BrH, and therefore the sensitive determination of BrH was possible. Under optimal conditions, the quenched ECL intensity was linear to the concentration of BrH in a wide range of 0.08 to 500μM, with a detection limit of 0.02μM (signal-to-noise ratio (S/N) = 3). This ECL method possessed the merits of rapid, simple and sensitive, and was successfully applied to the BrH quantification in pharmaceutical preparations with satisfactory recoveries of 91.0 ± 4.0 to 106.5 ± 3.4%. The possible route of the quenched ECL of luminol/H2O2 in the presence of BrH was also discussed.2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) were involved in the experimental procedure.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Quality Control of 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride

Reference:
Bromide – Wikipedia,
bromide – Wiktionary