Month: September 2022

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Reference of 20469-65-2.

Cheng, Bao;Zhu, Guirong;Meng, Linghua;Wu, Guolin;Chen, Qin;Ma, Shengming research published 《 Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance》, the research content is summarized as follows. Microtubule targeting agents (MTAs) are among the most successful chemotherapeutic drugs, but their efficacy is often limited by the development of multidrug resistance (MDR). Therefore, the development of novel MTAs with the ability to overcome MDR is urgently needed. In this contribution, through modification of the unsym. biaryl compounds, we discovered a novel compound dxy-1-175 with potent anti-proliferative activity against cancer cells. Mechanistic study revealed that dxy-1-175 inhibited tubulin polymerization by interacting with the colchicine-binding site of tubulin, which caused cell cycle arrest at G2/M phase. Based on the predicted binding model of dxy-1-175 with tubulin, a series of new 4-benzoylbiphenyl analogs were designed and synthesized. Among them, the hydrochloride compound 12e with improved solubility and good stability in human liver microsome, exhibited the most potent anti-proliferative activity with IC50 value in the low nanomolar range, and markedly inhibited the growth of breast cancer 4T1 xenograft in vivo. Notably, 12e effectively overcame P-gp-mediated MDR and our preliminary data suggested that 12e may not be a substrate of P-glycoprotein (P-gp). Taken together, our study reveals a novel MTA 12e targeting the colchicine-binding site with potent anticancer activity and the ability to circumvent MDR.

20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., Reference of 20469-65-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Reference of 4897-84-1.

Chen, Zimin;Zheng, Songlin;Wang, Zijie;Liao, Zixuan;Yuan, Weiming research published 《 Electron Donor-Acceptor Complex Enabled Photocyanation of Tertiary Amines with a Stable and User-Friendly Cyanobenziodoxolone Reagent》, the research content is summarized as follows. A visible light-induced photocyanation of tertiary amines e.g., 1-((trimethylsilyl)methyl)piperidine by a stable, less-toxic and user-friendly CN reagent cyanobenziodoxolone (CBX) was developed. This cyanation process does not require any photocatalyst, oxidant, base or additives, and represents a set of extremely mild and succinct reaction conditions and a broad substrate scope. In addition to the frequently used N-aryl amine derivatives e.g, 2-thiomorpholinoacetonitrile, more challenging tertiary aliphatic amines (modified by a α-silyl substituent) can also be photocyanated smoothly. Mechanistic studies reveal that the cyanation reaction is enabled by an electron donor-acceptor (EDA) complex formed by the interaction between the amine and the cyanobenziodoxolone reagent.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Reference of 4897-84-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4224-70-8, formula is C6H11BrO2, The most pervasive is the naturally produced bromomethane. Related Products of 4224-70-8

Chen, Zhen;Xie, Huan-Yin;Li, Yi-Jing;Chen, Gui-E.;Xu, Sun-Jie;Xu, Zhen-Liang research published 《 Smart light responsive polypropylene membrane switching reversibly between hydrophobicity and hydrophilicity for oily water separation》, the research content is summarized as follows. Smart membranes with switchable wettability are perfect choices for oily water separation, which limited in numerous practical applications as before. Hereof, one method of chem. grafting azobenzene groups on SiO2 roughened polypropylene (PP) membranes has been realized. This smart membrane surface reveals rapid light-triggered wettability transition between hydrophobicity and hydrophilicity through alternate irradiation with UV and Vis light, resp. After modification, maximal water contact angle (WCA) of 160° is obtained in the trans state of 7-[(trifluoromethoxyphenylazo)phenoxy]pentanoic acid (CF₃AZO), which convert into cis state by UV (365 nm) irradiation In cis state, since the high free energy of CF₃AZO, hydrophilic surface (WCA ≤ 5°) is acquired and can swap back to trans state under Vis (440 nm) irradiation Simultaneously, the photosensitive membranes possess exceptional phys. and chem. stabilities, which can endure cruel ambient conditions and repeated mech. deformation along with multiple rinsing. What’s more, on account of the outstanding photosensitivity, multifarious eliminable and reproducible patterns with apparent wetting characteristics upon optional illumination can be acquired. The pos. outcomes indicate that photosensitive CF₃AZO grafted PP membranes with outstanding switchable wettability is a prospective material for oil/water separation membranes.

Related Products of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Category: bromides-buliding-blocks.

Chen, Zhangxin;Mei, Shiwei;Li, Weijun;Xu, Ning;Dong, Yujie;Jin, Yanxian;Ouyang, Mi;Zhang, Cheng research published 《 Study of multi-electron redox mechanism via electrochromic behavior in hexaazatrinaphthylene-based polymer as the cathode of lithium-organic batteries》, the research content is summarized as follows. The charging and discharging mechanism of lithium-organic batteries has always been a challenging issue due to the lack of popularity of in situ characterization technol. during the charge/discharge process. In this article, a novel open lithium battery test combining the in situ electrochem. and UV spectral tests is firstly studied to explore the multi-electron redox mechanism of hexaazatrinaphthylene-based polymers as a cathode of lithium-organic batteries. Two triphenylamine-hexanazonaphthalene structure conjugated microporous polymers (PTPA-HATN and PDTPA-HATN) have been synthesized as models to study the charging and discharging mechanism of hexazanaphthalene. Both possess similar nanosphere morphol. and high surface area (~450 mA h g^-1) as well as abundant microporous structure. Using them as cathodes to explore the lithium battery performance, an obvious charge-discharge process with multi-electron redox characteristics can be observed in both, and the one with PTPA-HATN shows a higher discharge capacity (~168 mA h g^-1) and better rate performance than those of PDTPA-HATN in LiClO₄ electrolyte. Combining the in situ electrochem. and UV spectral results, a new multi-electron redox mechanism of hexanazonaphthalene-based polymer cathodes in lithium-organic batteries is proposed. Different from the previously reported mechanisms, the N and N lone electron pairs of the hexanazonaphthalene group in the polymer film will adsorb Li⁺ to form the N-Li-N bond in the electrolytes with low HF acid content accompanied with the red shift of absorption peak in the spectra under the open circuit voltage. During the discharge process, the N-Li-N bond will break and combine with the newly entered Li⁺ to form the N₂-Li₂ bond, resulting in a new large blueshift in the spectra. This work may provide new insight into the redox mechanism of functional groups of organic cathode materials via electrochromic behavior on the performance of lithium batteries.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Safety of 3,5-Dibromo-2-hydroxybenzaldehyde.

Chen, Yu-Xuan;Di, Jia-Qi;Geng, Shan-Shan;Zhang, Zhan-Hui research published 《 Application of potassium-modified carbon nitride as a highly efficient recyclable catalyst for synthesis of 4H-chromene derivatives》, the research content is summarized as follows. A potassium-doped carbon nitride (K-CN) was prepared by a simple thermal polymerization method. The prepared K-CN was characterized by Fourier IR spectroscopy (FT-IR), powder X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM) and XPS techniques. The obtained K-CN exhibited excellent catalytic activity for synthesis of 4H-chromene derivatives via one-pot three-component reaction of salicylaldehyde, cyclohexane-1,3-diones and 4-hydroxycoumarin in water/ethyl lactate at room temperature The reported method shows significant advantages, such as high yield, mild and clean reaction conditions, the use of recyclable catalyst and Et lactate/water as an environmentally friendly solvent, multi-component reaction at room temperature, no chromatog. separation and suitable for large-scale synthesis.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Safety of 3,5-Dibromo-2-hydroxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Organic compounds having carbon bonded to bromine are called organic bromides. Application of C7H4Br2O2.

Chen, Yue;Yang, Qi;Peng, Guo;Zhang, Yi-Quan;Ren, Xiao-Ming research published 《 Influence of F-position and solvent on coordination geometry and single ion magnet behavior of Co(II) complexes》, the research content is summarized as follows. Three mononuclear Co(II) complexes with the compositions of [Co(L₁)₂] (1), [Co(L₂)₂(MeCN)] (2) and [Co(L₃)₂] (3) (HL₁ = 2-((E)-(2-fluorobenzylimino)methyl)-4,6-dibromophenol, HL₂ = 2-((E)-(3-fluorobenzylimino)methyl)-4,6-dibromophenol and HL₃ = 2-((E)-(4-fluorobenzylimino)methyl)-4,6-dibromophenol) were prepared and structurally determined The changes in the F-positions in the ligands and solvents gave these products with various coordination geometries. Both complexes 1 and 3 are four-coordinated and their coordination geometries can be described as tetrahedron and seesaw, whereas complex 2 is five coordinated with a coordination configuration in between trigonal bipyramid and square pyramid. Static magnetic studies reveal that all these complexes exhibit considerable easy-axis magnetic anisotropy. The easy-axis magnetic anisotropy of 1 and 3 mainly derives from the first quartet excited state, whereas that of 2 primarily originates from the first, third and fourth quartet excited states established by theor. calculations All the resulting complexes display field-induced slow magnetic relaxation. Complex 3 represents the first Co(II) single ion magnet with a seesaw coordination geometry. Ab initio calculations predict that the magnetic anisotropy will enhance when the seesaw coordination geometry varies from distortion to regulation.

Application of C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., 90-59-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of C7H8BrN.

Chen, Yong-Jia;Liu, Hua;Zhang, Shao-Yong;Li, Hu;Ma, Kun-Yuan;Liu, Ying-Qian;Yin, Xiao-Dan;Zhou, Rui;Yan, Yin-Fang;Wang, Ren-Xuan;He, Ying-Hui;Chu, Qing-Ru;Tang, Chen research published 《 Design, Synthesis, and Antifungal Evaluation of Cryptolepine Derivatives against Phytopathogenic Fungi》, the research content is summarized as follows. Inspired by the widely antiphytopathogenic application of diversified derivatives from natural sources, cryptolepine and its derivatives were subsequently designed, synthesized, and evaluated for their antifungal activities against four agriculturally important fungi Rhizoctonia solani, Botrytis cinerea, Fusarium graminearum, and Sclerotinia sclerotiorum. The results obtained from in vitro assay indicated that compounds showed great fungicidal property against B. cinerea (EC₅₀ < 4μg/mL); especially, I presented significantly prominent inhibitory activity with an EC₅₀ of 0.027μg/mL. In the pursuit of further expanding the antifungal spectrum of cryptolepine, ring-opened compound II produced better activity with an EC₅₀ of 3.632μg/mL against R. solani and an EC₅₀ of 5.599μg/mL against F. graminearum. Furthermore, I was selected to be a candidate to investigate its preliminary antifungal mechanism to B. cinerea, revealing that not only spore germination was effectively inhibited and the normal physiol. structure of mycelium was severely undermined but also detrimental reactive oxygen was obviously accumulated and the normal function of the nucleus was fairly disordered. Besides, in vivo curative experiment against B. cinerea found that the therapeutic action of I was comparable to that of the pos. control azoxystrobin. These results suggested that compound I could be regarded as a novel and promising agent against B. cinerea for its valuable potency.

6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., Application of C7H8BrN

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Computed Properties of 20469-65-2.

Chen, Yixuan;Gu, Yuefei;Meng, Huan;Shao, Qianzhen;Xu, Zhenchuang;Bao, Wenjing;Gu, Yucheng;Xue, Xiao-Song;Zhao, Yanchuan research published 《 Metal-Free C-H Functionalization via Diaryliodonium Salts with a Chemically Robust Dummy Ligand》, the research content is summarized as follows. A two-step strategy for the transition-metal-free C-H functionalization of arenes using unsym. iodonium salts as versatile synthetic linchpins was presented. The key to the success of this strategy was the identification of the 3,5-dimethyl-4-isoxazolyl (DMIX) group as a superior dummy ligand, which enabled not only site-selective C-H functionalization to afford unsym. iodonium salts I [R = Ph, 2-thienyl, 3,4-di-ClC₆H₄, etc.; X = OAc, OTs], but also highly selective aryl transfer during the subsequent metal-free coupling reaction. Both electron-rich and moderately electron-deficient arenes could be converted into the iodonium salts through C-H functionalization, allowing for diverse structural elaboration by metal-free C-N, C-C, C-S, and C-O coupling.

20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., Computed Properties of 20469-65-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. SDS of cas: 823-78-9.

Chen, Yiming;Zhang, Lihui;Zhang, Lin;Jiang, Qixiao;Zhang, Lei research published 《 Discovery of indole-3-butyric acid derivatives as potent histone deacetylase inhibitors》, the research content is summarized as follows. In discovery of HDAC inhibitors (HDACIs) with improved anticancer potency, structural modification was performed on the previous derived indole-3-butyric acid derivative Among all the synthesized compounds, mol. I exhibited high HDAC inhibitory and antiproliferative potencies in the in vitro investigations. The IC₅₀ values of I against HDAC1, HDAC3, and HDAC6 were 13.9, 12.1, and 7.71 nM, resp. In the cancer cell based screening, mol. I showed increased antiproliferative activities in the inhibition of U937, U266, HepG2, A2780, and PNAC-1 cells compared with SAHA. In the HepG2 xenograft model, 50 mg/kg/d of I could inhibit tumor growth in athymic mice compared with 100 mg/kg/d of SAHA. Induction of apoptosis was revealed to play an important role in the anticancer potency of mol.I. Collectively, a HDACI (I) with high anticancer activity was discovered which can be utilized as a lead compound for further HDACI design.

SDS of cas: 823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., 823-78-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 5392-10-9, formula is C9H9BrO3, The most pervasive is the naturally produced bromomethane. HPLC of Formula: 5392-10-9

Chen, Yi;Liu, Di;Wang, Rui;Xu, Li;Tan, Jingyao;Shu, Mao;Tian, Lingfeng;Jin, Yuan;Zhang, Xiaoke;Lin, Zhihua research published 《 Bronsted Acid-Catalyzed : Synthesis of Phenanthrenes via Phosphomolybdic Acid as a Catalyst》, the research content is summarized as follows. Herein, disclosed a synthetic protocol for the synthesis of phenanthrenes such as I [R = H, Me; R¹ = H, Me, OMe, etc.; R² = H, F, OMe, etc.; R³ = H, OTIPS; R⁴ = H, F, Cl, etc.] through the CCOM with the inexpensive, nontoxic phosphomolybdic acid as a catalyst. The current annulations could realized carbonyl-olefin, carbonyl-alc., and acetal-alc. in situ CCOM reactions and feature mild reaction conditions, simple manipulation and scalability, making this strategy a promising alternative to the Lewis acid-catalyzed COM reaction.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., HPLC of Formula: 5392-10-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary