Barber, E. Ryan; Hynds, Hannah M.; Stephens, Claudia P.; Lemons, Holli E.; Fredrickson, Emily T.; Wilger, Dale J. published the artcile< Nickel-Catalyzed Hydroarylation of Alkynes under Reductive Conditions with Aryl Bromides and Water>, SDS of cas: 2725-82-8, the main research area is nickel catalyzed hydroarylation alkyne aryl bromide; reductive cross coupling alkyne arylbromide water anti selectivity.
An operationally simple nickel-catalyzed hydroarylation reaction for alkynes is described. This three-component coupling reaction utilizes com. available alkynes and aryl bromides, along with water and Zn. An air-stable and easily synthesized Ni(II) precatalyst is the only entity used in the reaction that is not com. available. This reductive cross-coupling reaction displays a fairly unusual anti selectivity when aryl bromides with ortho substituents are used. In addition to optimization data and a preliminary substrate scope, complementary experiments including deuterium labeling studies are used to provide a tentative catalytic mechanism. We believe this report should inspire and inform other Ni-catalyzed carbofunctionalization reactions.
Journal of Organic Chemistry published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, SDS of cas: 2725-82-8.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary