Dong, Kui; Jin, Xiao-Ling; Chen, Shihao; Wu, Li-Zhu; Liu, Qiang published the artcile< Controllable synthesis of 2- and 3-aryl-benzomorpholines from 2-aminophenols and 4-vinylphenols>, Category: bromides-buliding-blocks, the main research area is aryl benzomorpholine preparation diastereoselective chemoselective regioselective; aminophenol vinylphenol cross coupling heterocyclization rose bengal photocatalyst.
Herein, a method for the controllable synthesis of 3-aryl-benzomorpholine and 2-aryl-benzomorpholine cycloadducts I (R1 = H, 5-Me, 6-t-Bu, 6-Br, etc.; R2 = H, Me, Ph, Bn; R3 = H, Me, OMe, t-Bu; R4 = Me, OMe, OEt, t-Bu; R5 = Me, Et, OMe, CH1OH; R6 = H, Me) and II (R7 = H, 5-Me, 6-Br, 7-Cl, etc.; R8 = H, OMe, OEt, t-Bu) via cross-coupling/annulation between electron-rich 2-aminophenols 2-NH(R2)R1C6H3OH/2-NH2-R7C6H3OH and 4-vinylphenols 3-R3-4-OH-5-R4C6H2CH=CH(R5)R6/ 3-R3-4-OH-5-R8C6H2CH=CH(R5)R6 was presented. Mol. oxygen was successfully used in the reaction as the terminal oxidant and the complete inversion of chemoselectivity was achieved by the adjustment of the solvents and bases at room temperature
Chemical Communications (Cambridge, United Kingdom) published new progress about Chemoselectivity. 1530-33-2 belongs to class bromides-buliding-blocks, and the molecular formula is C21H22BrP, Category: bromides-buliding-blocks.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary