Huang, Liangbin; Ackerman, Laura K. G.; Kang, Kai; Parsons, Astrid M.; Weix, Daniel J. published the artcile< LiCl-Accelerated Multimetallic Cross-Coupling of Aryl Chlorides with Aryl Triflates>, Electric Literature of 576-83-0, the main research area is aryl chloride triflate palladium nickel zinc lithium chloride; biaryl preparation; palladium nickel coupling catalyst; zinc reducing agent; lithium chloride promoter.
While the synthesis of biaryls has advanced rapidly in the past decades, cross-Ullman couplings of aryl chlorides, the most abundant aryl electrophiles, have remained elusive. Reported here is a general cross-Ullman coupling of aryl chlorides with aryl triflates. The selectivity challenge associated with coupling an inert electrophile with a reactive one is overcome using a multimetallic strategy with the appropriate choice of additive. Studies demonstrate that LiCl is essential for effective cross-coupling by accelerating the reduction of Ni(II) to Ni(0) and counteracting autoinhibition of reduction at Zn(0) by Zn(II) salts. The modified conditions tolerate a variety of functional groups on either coupling partner (42 examples), and examples include a three-step synthesis of flurbiprofen.
Journal of the American Chemical Society published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Electric Literature of 576-83-0.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary