Shan, Chao; Cao, Liming; Yang, Jiasheng; Cheng, Ruihua; Yao, Xiantong; Liang, Chaoming; Sun, Maolin; Ye, Jinxing published the artcile< Construction of an α-chiral pyrrolidine library with a rapid and scalable continuous flow protocol>, Safety of 2,4,6-Trimethylbromobenzene, the main research area is chloro tert butanesulfinyl imine grignard reagent continuous flow heterocyclization; tert butylsulfinyl pyrrolidine preparation enantioselective diastereoselective.
An α-chiral pyrrolidine library was established via a highly diastereoselective continuous flow protocol under mild conditions. Various functionalized pyrrolidines was obtained in generally high yields (up to 87%) and with superior diastereocontrol within 150 s. The utility of this flow methodol. was further demonstrated by the gram-scale preparation of a κ-opioid receptor selective antagonist Aticaprant intermediate. Moreover, the scale-up in a self-designed microfluidic reactor provided a throughput of 7.45 g h-1, suggesting its potential large-scale applications. The flow procedure afforded rapid, cost-efficient and scalable access to obtain chiral α-substituted pyrrolidines in the compound library.
Reaction Chemistry & Engineering published new progress about Bromoalkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Safety of 2,4,6-Trimethylbromobenzene.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary