Zhou, Jiadi; Jiang, Xinpeng; Jin, Can; Guo, Zhicheng; Su, Bin; Su, Weike published the artcile< One-Pot L-Proline-Mediated Stereoselective α-C(sp2)-H Fluorination of α,β-Unsaturated Aldehydes through Methoxyfluorination-Elimination>, Application In Synthesis of 3893-18-3, the main research area is fluoro unsaturated alc preparation diastereoselective; unsaturated aldehyde Selectfluor fluorination proline catalyst.
A one-pot, two-step L-proline-mediated stereoselective α-C(sp2)-H fluorination of α,β-unsaturated aldehydes RHC=CHCHO (R = 2-ClC6H4, 2-naphthyl, (CH2)2CH3, etc.) towards their corresponding (Z)-α-fluoro-αβ-unsaturated aldehydes (Z)-RHC=C(F)CHO has been developed. The first step utilizes Selectfluor as a fluorinating agent in CH3NO2/MeOH forming (Z)-α-fluoro-α,β-unsaturated aldehydes and their corresponding di-Me acetals through methoxyfluorination-elimination. In the second step, water is added to promote the hydrolytic cleavage of the di-Me acetals. The obtained (Z)-α-fluoro-α,β-unsaturated aldehydes were smoothly reduced to the corresponding alcs. (Z)-RHC=C(F)CH2OH by using NaBH4.
European Journal of Organic Chemistry published new progress about Alcohols, unsaturated Role: SPN (Synthetic Preparation), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application In Synthesis of 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary