Gensch, Tobias; Smith, Sleight R.; Colacot, Thomas J.; Timsina, Yam N.; Xu, Guolin; Glasspoole, Ben W.; Sigman, Matthew S. published the artcile< Design and Application of a Screening Set for Monophosphine Ligands in Cross-Coupling>, Application of C9H11Br, the main research area is arene aryl boronic acid palladium phosphine Suzuki coupling; bromobenzene aminobenzimidazole palladium phosphine chemoselective Buchwald Hartwig amination.
A virtual library, kraken, which is representative of the monodentate P(III)-ligand chem. space, was utilized as the basis to represent the discrete ligands as continuous variables. Using dimensionality reduction and clustering techniques, a Phosphine Optimization Screening Set (PHOSS) of 32 com. available ligands was suggested that samples this chem. space completely and evenly. The application of this screening set was presented in the identification of active catalysts for various cross-coupling reactions and show how well-distributed sampling of the chem. space facilitates identification of active catalysts. Furthermore, how proximity in ligand space can be a useful guide to further explore ligands when very few active catalysts are known was demonstrated.
ACS Catalysis published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Application of C9H11Br.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary