Bao, Lan; Liu, Yu; Peng, Jinghan; Wang, Yuan; Dong, Jinhuan; Xu, Xianxiu published the artcile< Chemoselective Trimerization of Isocyanides: De Novo Synthesis of 2-Indole-Substituted Quinolines and Pyridines>, Name: 3-(4-Bromophenyl)acrylaldehyde, the main research area is indolylquinoline preparation chemoselective; indolylpyridine preparation chemoselective; isocyanide tandem trimerization reaction.
A catalyst-free chemoselective trimerization reaction of readily available isocyanides 2-NC-4-R-5-R1C6H2C(R2)=CH2 (R = H, OMe; R1 = H, OMe, Cl; R2 = H, CF3, Ph, 4-fluorophenyl, 4-methoxyphenyl), R3CH=CH-CH=C(R4)NC (R3 = C(O)OEt, Ts; R4 = Ph, 4-bromophenyl, 4-methoxyphenyl), 2-R5-3-R6-4-R7-5-R8C6HNC (R5 = H, Me; R6 = H, OMe, Me; R5R6 = -CH=CH-CH=CH-; R7 = H, Me, Br, C(O)Ph, etc.; R6R7 = -CH=CH-CH=CH-; R8 = H, Me, OMe) and 3-isocyanothiophene is described. This domino reaction provides facile access to a wide range of 2-(indol-2-yl)-quinolines I, II and 2-(indol-2-yl)-pyridines III in moderate to excellent yields. A “”head to head”” heterodimerization of two isocyanides is proposed as the key step of this reaction.
Organic Letters published new progress about Chemoselectivity. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Name: 3-(4-Bromophenyl)acrylaldehyde.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary