Hu, Xiao-Qiang; Liu, Zi-Kui; Hou, Ye-Xing; Zhang, Guodong; Gao, Yang published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Ru-catalyzed C(sp2)-H vinylation/annulation of benzoic acids and alkynes: rapid access to medium-sized lactones》.Formula: C8H7BrO2 The article contains the following contents:
An unprecedented ruthenium catalyzed [4+4] annulation of readily available benzoic acids and alkynes was reported. The carboxylate group acted as both a directing group and an internal nucleophilic reagent to facilitated a C(sp2)-H vinylation/annulation cascade. This reaction avoided the classically oxidative [4+2] annulation, allowed the efficient synthesis of a wide array of eight-membered lactones under oxidant-free conditions. Moreover, this catalytic system would be successfully extended to [4+3] and [4+5] annulations for the assembly of seven- and nine-membered lactones. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Formula: C8H7BrO2)
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C8H7BrO2 In contrast, terrestrial plants account only for a few bromine-containing compounds.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary