Huang, Wenyi; Shrestha, Mohini; Wang, Chenchen; Fang, Ke; Teng, Yaxin; Qu, Jingping; Chen, Yifeng published the artcile< Asymmetric synthesis of 3-benzyl and allyl isoindolinones by Pd-catalyzed dicarbofunctionalization of 1,1-disubstituted enamides>, Application of C7H4BrNO4, the main research area is disubstituted isoindolinone enantioselective preparation; boronic acid disubstituted enamide tandem Heck Suzuki palladium catalyst.
A palladium-catalyzed asym. synthesis of 3,3-disubstituted isoindolinones I [R = (E)-n-BuCH=CH, 3-thienyl, PMB, etc.; R1 = Bn, (CH2)2Ph, PMB; R2 = Me, iPr; R3 = H, 6-Cl, 5-NO2; etc.] via tandem Heck/Suzuki coupling of 1,1-disubstituted enamides with aryl/alkenyl boronic acids under mild reaction conditions was reported. This reaction exhibited both broad functional group tolerance and high enantioselectivity. The first dicarbo-functionalization of 1,1-disubstituted enamides to generate amide derivatives bearing quaternary stereocenters was reported. Finally, synthetic utility of this protocol was demonstrated by expedient synthesis of PI3K-delta inhibitor precursor.
Organic Chemistry Frontiers published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (enamides). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Application of C7H4BrNO4.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary