Mondal, Anirban; Visser, Paco; Doze, Anna M.; Buter, Jeffrey; Feringa, Ben L. published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Pd-catalyzed sp-sp3 cross-coupling of benzyl bromides using lithium acetylides》.COA of Formula: C9H9BrO2 The article contains the following contents:
An efficient method for the cross-coupling of benzyl bromides (sp3) with lithium acetylides (sp) was developed to obtain benzylic alkynes I [R = H, 3-MeO, 4-Me, etc.; R1 = Si(CH3)3, Si(i-Pr)3, Ph, 9-phenanthryl]. The reaction proceeded within 10 min at room temperature and could be performed in the presence of organolithium-sensitive functional groups such as esters, nitriles, amides and boronic esters. The potential application of the methodol. was demonstrated in the preparation of key intermediates used in pharmaceuticals, chem. biol. and natural products. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8COA of Formula: C9H9BrO2)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. COA of Formula: C9H9BrO2 Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary