The author of 《A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo》 were Paranawithana, Namini N.; Martins, Andre F.; Clavijo Jordan, Veronica; Zhao, Piyu; Chirayil, Sara; Meloni, Gabriele; Sherry, A. Dean. And the article was published in Journal of the American Chemical Society in 2019. Related Products of 1129-28-8 The author mentioned the following in the article:
The design, synthesis, and properties of a new gadolinium-based copper-responsive magnetic resonance imaging (MRI) contrast agent is presented. The sensor (GdL1) has high selectivity for copper ions and exhibits a 43% increase in r1 relaxivity (20 MHz) upon binding to 1 equiv of Cu2+ in aqueous buffer. Interestingly, in the presence of physiol. levels of human serum albumin (HSA), the r1 relaxivity is amplified further up to 270%. Addnl. spectroscopic and X-ray absorption spectroscopy (XAS) studies show that Cu2+ is coordinated by two carboxylic acid groups and the single amine group on an appended side chain of GdL1 and forms a ternary complex with HSA (GdL1-Cu2+-HSA). T1-weighted in vivo imaging demonstrates that GdL1 can detect basal, endogenous labile copper(II) ions in living mice. This offers a unique opportunity to explore the role of copper ions in the development and progression of neurol. diseases such as Wilson’s disease. The experimental process involved the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Related Products of 1129-28-8)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Related Products of 1129-28-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary