Name: Methyl 3-(bromomethyl)benzoateIn 2018 ,《A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry. The article was written by Xu, Guangwei; Wang, Tianqi; Li, Yongtao; Huang, Zhi; Wang, Xin; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong. The article contains the following contents:
Indoleamine 2,3-dioxygenase 1 (IDO1) activity links to immune escape of cancers. Inhibition of IDO1 provides a new approach for cancer treatment. Most clin. IDO1 drugs show marginal efficacy as single agents. On basis of mol. docking and pharmacophore modeling, a novel inhibitor Roxyl-WL was discovered with a half maximal inhibitory concentration (IC50) value of 1 nM against IDO1 and 10-100-fold increased potent activity compared with IDO1 drugs in clin. trials. Roxyl-WL displayed excellent kinase spectrum selectivity with no activity out of the 337 protein kinases. In vitro, Roxyl-WL effectively augmented the proliferation of T cells and reduced the number of regulatory T cell (Tregs). When administered to melanoma (B16F10) tumor-bearing mice orally, Roxyl-WL significantly suppressed tumor growth and induced immune response. The experimental process involved the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Name: Methyl 3-(bromomethyl)benzoate)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Name: Methyl 3-(bromomethyl)benzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary