Zhang, Yong; Wei, Biaowen; Lin, Hui; Cui, Weirong; Zeng, Xianqiang; Fan, Xiaolin published the artcile< Organocatalyzed Asymmetric Vinylogous Michael Reactions of 3,5-Dialkyl-Substituted 4-Nitroisoxazoles: A Direct Method for the Synthesis of Chiral Isoxazole Derivatives>, Computed Properties of 3893-18-3, the main research area is isoxazole preparation enantioselective; aldehyde unsaturated nitroisoxazole vinylogous Michael addition organocatalyst.
A direct method for the synthesis of chiral isoxazole derivatives I (R = 3-BrC6H4, naphth-1-yl, 2-thienyl, etc.) via asym. vinylogous Michael addition of 3,5-dialkyl-substituted 4-nitroisoxazoles with α,β-unsaturated aldehydes catalyzed by a diphenylprolinol TBS ether organocatalyst is described. This approach provides an easy access to highly functionalized chiral isoxazole derivatives with moderate to good yields and up to excellent enantioselectivities (96% ee).
Advanced Synthesis & Catalysis published new progress about Acetals Role: SPN (Synthetic Preparation), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Computed Properties of 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary