Recommanded Product: 1-Bromo-2-((methylsulfonyl)methyl)benzeneOn May 9, 2013 ,《Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Christiansen, Elisabeth; Hansen, Steffen V. F.; Urban, Christian; Hudson, Brian D.; Wargent, Edward T.; Grundmann, Manuel; Jenkins, Laura; Zaibi, Mohamed; Stocker, Claire J.; Ullrich, Susanne; Kostenis, Evi; Kassack, Matthias U.; Milligan, Graeme; Cawthorne, Michael A.; Ulven, Trond. The article conveys some information:
Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist (I) with favorable physicochem. and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing. In the experiment, the researchers used 1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2Recommanded Product: 1-Bromo-2-((methylsulfonyl)methyl)benzene)
1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: 1-Bromo-2-((methylsulfonyl)methyl)benzene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary