《Atropisomerism in diarylamines: structural requirements and mechanisms of conformational interconversion》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Costil, Romain; Sterling, Alistair J.; Duarte, Fernanda; Clayden, Jonathan. Formula: C9H11Br The article mentions the following:
In common with other hindered structures containing two aromatic rings linked by a short tether, diarylamines may exhibit atropisomerism (chirality due to restricted rotation). Previous examples have principally been tertiary amines, especially those with cyclic scaffolds. Little is known of the structural requirement for atropisomerism in structurally simpler secondary and acyclic diarylamines. In this paper we describe a systematic study of a series of acyclic secondary diarylamines, and we quantify the degree of steric hindrance in the ortho positions that is required for atropisomerism to result. Through a detailed exptl. and computational anal., the role of each ortho-substituent on the mechanism and rate of conformational interconversion is rationalized. We also present a simple predictive model for the design of configurationally stable secondary diarylamines. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Formula: C9H11Br)
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Formula: C9H11Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary