《Regioselective C-H Hydroarylation of Internal Alkynes with Arenecarboxylates: Carboxylates as Deciduous Directing Groups》 was written by Huang, Liangbin; Biafora, Agostino; Zhang, Guodong; Bragoni, Valentina; Goossen, Lukas J.. Application of 76006-33-2This research focused onvinylbenzoic acid ester regioselective synthesis; benzoic acid alkyne hydroarylation Ru catalyst guanidine carbonate; C−H activation; alkynes; decarboxylation; ruthenium; synthetic methods. The article conveys some information:
In the presence of catalytic [Ru(p-cym)I2]2 and the base guanidine carbonate, benzoic acids react with internal alkynes to give the corresponding 2-vinylbenzoic acids. This alkyne hydroarylation is generally applicable to diversely substituted electron-rich and electron-poor benzoic and acrylic acids. Aryl(alkyl)acetylenes react regioselectively with formation of the alkyl-branched hydroarylation products, and propargylic alcs. are converted into γ-alkylidene-δ-lactones. The hydroarylation can also be conducted decarboxylatively with a different choice of catalyst and reaction conditions. This reaction variant, which does not proceed via intermediate formation of 2-vinylbenzoic acids, e. g., I, opens up a regioselective, waste-minimized synthetic entry to vinylarenes.3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Application of 76006-33-2) was used in this study.
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Application of 76006-33-2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary