In 2009,Kasuga, Jun-ichi; Ishida, Seiichi; Yamasaki, Daisuke; Makishima, Makoto; Doi, Takefumi; Hashimoto, Yuichi; Miyachi, Hiroyuki published 《Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ selective antagonists》.Bioorganic & Medicinal Chemistry Letters published the findings.Reference of 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:
Novel PPARδ antagonists were designed and synthesized based on the crystal structure of the PPARδ full agonist TIPP-204 bound to the PPARδ ligand-binding domain, in combination with the nuclear receptor helix 12 folding modification hypothesis. Representative compound I exhibits PPARδ-preferential antagonistic activity. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Reference of 3-Bromo-2-methylbenzoic acid)
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Reference of 3-Bromo-2-methylbenzoic acid Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary