In 2015,Kusumi, Kensuke; Shinozaki, Koji; Kanaji, Toshiya; Kurata, Haruto; Naganawa, Atsushi; Otsuki, Kazuhiro; Matsushita, Takeshi; Sekiguchi, Tetsuya; Kakuuchi, Akito; Seko, Takuya published 《Discovery of novel S1P2 antagonists. Part 1: Discovery of 1,3-bis(aryloxy)benzene derivatives》.Bioorganic & Medicinal Chemistry Letters published the findings.Recommanded Product: 76006-33-2 The information in the text is summarized as follows:
The structure-activity relationships of a novel series of sphingosine-1-phosphate receptor antagonists have been examined in detail. The initial hit compound 1 was modified through synthesis to improve its S1P2 activity. The synthesis of a series of analogs revealed that 1,3-bis(aryloxy)benzene derivatives, as represented by 22, are potent and selective S1P2 antagonists.3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Recommanded Product: 76006-33-2) was used in this study.
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: 76006-33-2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary