《Synthesis and inhibitory effect of cis-guggulsterone on lipopolysaccharide-induced production of nitric oxide in macrophages》 was written by Park, Jun Yeon; Lee, Jae Wook; Lee, Chang-Ho; Lee, Hae-Jeung; Kang, Ki Sung. Electric Literature of C20H20BrPThis research focused ontrans guggulsterone preparation antiinflammatory activity nitric oxide macrophage; COX-2; Guggulsterone; Inflammation; RAW264.7; iNOS. The article conveys some information:
Guggulsterone is a bioactive plant sterol naturally found in migratory plants. It exists in various forms, and its active compounds include the isomers cis-guggulsterone (I, E-GS) and trans-guggulsterone (Z-GS). In this study, the anti-inflammatory effects of these two isomeric pregnadienedione steroids were investigated against lipopolysaccharide-induced inflammatory reaction in RAW264.7 mouse macrophages. Our results showed that both guggulsterones inhibited the production of NO in macrophages treated with lipopolysaccharide, with IC50 values ranging from 3.0 to 6.7μM. E-GS exerted higher efficacy than Z-GS, and its anti-inflammatory effects was mediated through inhibition of iNOS and COX-2 expression. In the experimental materials used by the author, we found Ethyltriphenylphosphonium bromide(cas: 1530-32-1Electric Literature of C20H20BrP)
Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Electric Literature of C20H20BrP
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary