《Development of a Scalable and Practical Synthesis of AB928, a Dual A2a/A2b Receptor Antagonist》 was written by Sharif, Ehesan U.; Miles, Dillon H.; Rosen, Brandon R.; Jeffrey, Jenna L.; Debien, Laurent P. P.; Powers, Jay P.; Leleti, Manmohan R.. Reference of 3-Bromo-2-methylbenzoic acid And the article was included in Organic Process Research & Development in 2020. The article conveys some information:
First- and second-generation routes to the dual A2a/A2b receptor antagonist AB928 I are disclosed. The second-generation route (performed on multigram scale) prepared the aminochloropyridinylbenzonitrile II by a route avoiding palladium-catalyzed borylation and Suzuki coupling reactions required in the initial route which generated significant amounts of byproducts. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Reference of 3-Bromo-2-methylbenzoic acid)
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Reference of 3-Bromo-2-methylbenzoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary