The author of 《Development of thiazolidinedione-based HDAC6 inhibitors to overcome methamphetamine addiction》 were Sharma, Chiranjeev; Oh, Yong Jin; Park, Byoungduck; Lee, Sooyeun; Jeong, Chul-Ho; Lee, Sangkil; Seo, Ji Hae; Seo, Young Ho. And the article was published in International Journal of Molecular Sciences in 2019. Computed Properties of C9H9BrO2 The author mentioned the following in the article:
Thiazolidinedione is a five-membered heterocycle that is widely used in drug discovery endeavors. In this study, we report the design, synthesis, and biol. evaluation of a series of thiazolidinedione-based HDAC6 inhibitors. In particular, compound 6b exerts an excellent inhibitory activity against HDAC6 with an IC50 value of 21 nM, displaying a good HDAC6 selectivity over HDAC1. Compound 6b dose-dependently induces the acetylation level of alpha-tubulin via inhibition of HDAC6 in human neuroblastoma SH-SY5Y cell line. Moreover, compound 6b efficiently reverses methamphetamine-induced morphol. changes of SH-SY5Y cells via regulating acetylation landscape of α-tubulin. Collectively, compound 6b represents a novel HDAC6-isoform selective inhibitor and demonstrates promising therapeutic potential for the treatment of methamphetamine addiction. The results came from multiple reactions, including the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Computed Properties of C9H9BrO2)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Computed Properties of C9H9BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary