Sun, Yue; Yang, Zi-Hui; Gu, Wen published the artcile< Synthesis, crystal structure and antifungal activity of new furan-1,3,4-oxadiazole carboxamide derivatives>, Formula: C7H8BrN, the main research area is furan oxadiazole carboxamide preparation antifungal activity crystal structure.
A series of novel furan-1,3,4-oxadiazole carboxamide derivatives I (R = H, Me, Br, Cl, F) were designed, synthesized and characterized by spectroscopic methods including HR-MS, 1H- and 13C-NMR. The crystal structure of compound I (R = Br) was determined by single-crystal X-ray diffraction. The compound crystallizes in the triclinic system, space group P1 with a = 4.7261(5), b = 10.4672(11), c = 14.5886(13) Å, α = 106.081(4)°, β = 91.043(3)°, γ = 99.456(4)°, Z = 2, V = 682.48(12) Å3, Mr = 348.16, Dc = 1.694 Mg/m3, S = 1.008, μ = 3.025 mm-1, F(000) = 348, the final R = 0.0775 and wR = 0.2080 for 2774 observed reflections (I > 2σ(I)). There are two kinds of hydrogen bonds (N(3)-H(3A)…N(2) and C(8)-H(8A)…O(3)) present in its crystal structure. The preliminary antifungal assay showed that compounds I (R = Cl, F) exhibited significant antifungal activities against several plant pathogenic fungi.
Chinese Journal of Structural Chemistry published new progress about Amides Role: PAC (Pharmacological Activity), PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary