Zhan, Bei-Bei; Jia, Zhen-Sheng; Luo, Jun; Jin, Liang; Lin, Xu-Feng; Shi, Bing-Feng published the artcile< Palladium-Catalyzed Directed Atroposelective C-H Allylation via β-H Elimination: 1,1-Disubstituted Alkenes as Allyl Surrogates>, Recommanded Product: 2-Bromo-4-isopropylaniline, the main research area is unsaturated ester enantioselective synthesis allylation elimination alkene methacrylate; allylation palladium catalyst.
Transition-metal-catalyzed dehydrogenative C-H allylation with 1,1-disubstituted alkenes via β-H elimination remains challenging, because of the low reactivity and difficulty of controlling selectivity. Herein, the development of a Pd(II)-catalyzed directed atroposelective C-H allylation with methacrylates is described. Exclusive allylic selectivity was achieved. A vast array of axially chiral biaryl-2-amines are efficiently synthesized with excellent enantioselectivities (up to >99% enantiomeric excess).
Organic Letters published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Recommanded Product: 2-Bromo-4-isopropylaniline.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary