Yang, Tianbao; Lu, Huiai; Qiu, Renhua; Hong, Ling; Yin, Shuang-Feng; Kambe, Nobuaki published the artcile< Photocatalyst-free Synthesis of Indazolones under CO2 Atmosphere>, Safety of 4-Bromobenzylamine, the main research area is indazolone dihydro preparation green chem anticancer activity; amine nitroaryl methanol heterocyclization; anticancer; indazolones; metal-free; photocatalyst-free; synthetic methods.
A convenient photocatalyst-free method for the synthesis of redox-active 1,2-dihydro-3H-indazol-3-one derivatives I (R = benzyl, thiophen-2-ylmethyl, cyclopropylmethyl, iso-Pr, etc.; R1 = H, Br, 3-methylphenyl, 4-methoxyphenyl, naphth-1-yl, furan-3-yl, thiophen-3-yl; R2 = H, Cl) from (2-nitroaryl)methanols 2-O2N-4-R1-5-R2C6H2CH2OH and amines RNH2 was developed. The reaction proceeded efficiently at room temperature by irradiation of UV light under CO2 atmosphere (1.0 atm, flow) without any photocatalysts or additives. This mild, operationally simple method shows wide functional tolerance. The carbamate formed in situ from CO2 and amine is proposed to be the key of this reaction. Some of these compounds synthesized by the present method were found to exhibit high anticancer activities, which can lower the viability of cancerous cell lines such as HeLa, MCF-7 and U87.
Chemistry – An Asian Journal published new progress about Antitumor agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary