《Synthesis of 2-Aminoquinazoline- and 2-Aminopyrimidine-Fused Hybrid Scaffolds by Copper-Catalyzed C(sp2)-N Coupling and Cyclization Followed by Oxidation》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Kwak, Jung Pyo; Dao, Pham Duy Quang; Cho, Chan Sik. Electric Literature of C7H5BrO The article mentions the following:
2-(2-Bromoaryl)- and 2-(2-bromovinyl)-4,7-dimethoxybenzimidazoles are coupled and cyclized with cyanamide as a building block in DMF in the presence of a catalytic amount of a copper catalyst along with a base to give the corresponding 2-aminoquinazoline- and 2-aminopyrimidine-fused 4,7-dimethoxybenzimidazoles in good yields. Subsequent oxidation of such N-fused hybrid scaffolds by treatment of ceric ammonium nitrate in acetonitrile/H2O affords unprecedented 2-aminoquinazoline- and 2-aminopyrimidine-fused benzimidazolequinones. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Electric Literature of C7H5BrO)
o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Electric Literature of C7H5BrOIt is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary