《Discovery of Novel 3,4-Dichloroisothiazole-Containing Coumarins as Fungicidal Leads》 was written by Lv, You; Liu, Hanlu; Wang, Lifan; Li, Kun; Gao, Wei; Liu, Xiaoyu; Tang, Liangfu; Kalinina, Tatiana A.; Glukhareva, Tatiana V.; Fan, Zhijin. COA of Formula: C4H6BrFO2 And the article was included in Journal of Agricultural and Food Chemistry on April 14 ,2021. The article conveys some information:
Natural products are one of the resources for discovering novel fungicidal leads. As a natural fungicide, osthole was used as a coumarin-based lead compound for the development of novel fungicides. Here, a series of 3,4-dichloroisothiazole-containing 7-hydroxycoumarins were rationally designed, synthesized, and characterized by introducing a bioactive substructure, 3,4-dichloroisothiazole, into the coumarin skeleton. In vitro bioassay indicated that compound (I) displayed good activity against Rhizoctonia solani, Physalospora piricola, Sclerotinia sclerotiorum, and Botrytis cinerea. Its median effective concentration (EC50) value against each of these fungi fell between 0.88 and 2.50μg/mL, which was much lower than that of osthole against the corresponding pathogen (between 7.38 and 74.59μg/mL). In vivo screening validated that (II) exhibited 100%, 60%, and 20% efficacy against R. solani at 200, 100, and 50μg/mL, resp. RNA sequence anal. implied that growth inhibition of R. solani by II might result from potential disruptions of fungal membrane formation and intracellular metabolism Furthermore, a field experiment with cucumber plants indicated that (III) showed 62.73% and 74.03% efficacy against Pseudoperonospora cubensis (Berk. & Curt.) Rostov. at rates of 12.5 g a.i./ha and 25 g a.i./ha, resp., which showed no significant difference between III and osthole at 30 g a.i./ha. Our studies suggested that III, I, and II might be used as fungicidal leads for further optimization. The experimental process involved the reaction of Ethylbromofluoroacetate(cas: 401-55-8COA of Formula: C4H6BrFO2)
Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.COA of Formula: C4H6BrFO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary