Peng, Fu; Zhao, Qian; Huang, Wei; Liu, Shuai-Jiang; Zhong, Ya-Jun; Mao, Qing; Zhang, Nan; He, Gu; Han, Bo published the artcile< Amine-catalyzed and functional group-controlled chemo- and regioselective synthesis of multi-functionalized CF3-benzene via a metal-free process>, Application of C9H7BrO, the main research area is arylpropenal fluoroalkyl cyanobutenoate amine tandem Rauhut Currier reaction; fluoroalkyl biaryl ester preparation chemoselective regioselective green chem; trifluoromethyl oxopentenoate arylpropenal amine tandem Michael reaction; formyl trifluoromethyl terphenyl ester preparation regioselective chemoselective green chem; phenyl butenoate cinnamaldehyde amine chemoselective regioselective Rauhut Currier reaction; diphenyl ester preparation green chem.
A new strategy for the preparation of CF3-containing multi-substituted benzene compounds via an amine-catalyzed reaction under metal-free and air-tolerant conditions was developed. This green reaction provided a functional group-controlled synthetic strategy and the polysubstituted benzene derivatives were obtained in moderate to good yields. Using a tri-substituted alkene containing a cyano group as the starting material, CF3-functionalized benzene compounds with four adjacent substituents were formed via a Rauhut-Currier (RC) reaction-triggered [3 + 3] cascade. When the cyano group was replaced with a benzoyl group, Michael-initialized [4 + 2] aromatization occurred, producing the corresponding CF3-benzene with five contiguous substituent groups. The reaction also features numerous advantages, including excellent chemo- and regioselectivity, extensive substrate scope and environmentally friendly conditions. A simple conversion of an aldehyde into a terminal alkyne was also achieved and the utility of this environmentally compatible method and the one-pot reaction was demonstrated by synthesizing a CF3-functionalized benzene-zidovudine hybrid.
Green Chemistry published new progress about [3+3] Cycloaddition reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application of C9H7BrO.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary