In 2019,Angewandte Chemie, International Edition included an article by Wu, Shuo; Wu, Xinxin; Wang, Dongping; Zhu, Chen. Computed Properties of C4H6BrFO2. The article was titled 《Regioselective Vinylation of Remote Unactivated C(sp3)-H Bonds: Access to Complex Fluoroalkylated Alkenes》. The information in the text is summarized as follows:
Regioselective incorporation of a particular functional group into aliphatic sites by direct activation of unreactive C-H bonds is of great synthetic value. Despite advances in radical-mediated functionalization of C(sp3)-H bonds by a hydrogen-atom transfer process, the site-selective vinylation of remote C(sp3)-H bonds still remains underexplored. Reported herein is a new protocol for the regioselective vinylation of unactivated C(sp3)-H bonds. The remote C(sp3)-H activation is promoted by a C-centered radical instead of the commonly used N and O radicals. The reaction possesses high product diversity and synthetic efficiency, furnishing a plethora of synthetically valuable E alkenes bearing tri-/di-/mono-fluoromethyl and perfluoroalkyl groups. The experimental process involved the reaction of Ethylbromofluoroacetate(cas: 401-55-8Computed Properties of C4H6BrFO2)
Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Computed Properties of C4H6BrFO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary