In 1980,Yagoub, Ahmed K.; Iskander, George M. published 《Evidence for the mechanism of formation of N-(1,2-dihydrobenzocyclobut-1-enyl)pyridinium bromides and acetophenones from bisdibromocyclopropane adducts》.Journal of the Chemical Society published the findings.Synthetic Route of C8H7BrO2 The information in the text is summarized as follows:
Bis(dibromocarbene) adducts I (R = H, R1 = OMe, OEt; R = Me, R1 = OMe) on heating with xylene and 1,4-diazabicyclo[2.2.2]octane gave the corresponding bicyclooctadienes II, which gave pyridinium salts III with pyridine). In contrast, reaction of pyridine with I (R = Me; R1 = OMe, OEt) and with bicyclic ketone IV gave phenylacylpyridinium salt V. The preparation of 4,2,3-MeO(Br)2C6H2COMe from I (R = H, R1 = OMe) is also reported. In addition to this study using 3-Bromo-2-methylbenzoic acid, there are many other studies that have used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Synthetic Route of C8H7BrO2) was used in this study.
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Synthetic Route of C8H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary