《Rhodium(III)-catalyzed tandem C-H olefination and oxidative cyclization of aromatic acids with acrylates for the synthesis of (E)-3-ylidenephthalides》 was written by Han, Wen-Jing; Pu, Fan; Fan, Juan; Liu, Zhong-Wen; Shi, Xian-Ying. Application In Synthesis of 3-Bromo-2-methylbenzoic acidThis research focused onylidenephthalide regioselective diastereoselective preparation; benzoic acid acrylate rhodium catalyst tandem olefination oxidative cyclization. The article conveys some information:
Intermol. tandem C-H olefination/C-O cyclization was achieved via a rhodium (III)-catalyzed C-H activation of carboxylic acids with acrylates. Direct and efficient construction of biol. relevant (E)-3-ylidenephthalide I [R = 4-Me, 4-Me-5-MeO, 4-Me-6-Cl, etc.; R1 = Me, Et, t-Bu, n-Bu] scaffolds with satisfactory to good yields was synthesized and characterized by stoichiometric reactants, exclusive stereoselectivity, com. available substrates, mild atm. conditions and short reaction time (less than 2 h). The experimental part of the paper was very detailed, including the reaction process of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Application In Synthesis of 3-Bromo-2-methylbenzoic acid)
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Application In Synthesis of 3-Bromo-2-methylbenzoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary