Synthetic Route of C4H7BrO2In 2016 ,《Bacterial versus human sphingosine-1-phosphate lyase (S1PL) in the design of potential S1PL inhibitors》 was published in Bioorganic & Medicinal Chemistry. The article was written by Sanllehi, Pol; Abad, Jose-Luis; Casas, Josefina; Bujons, Jordi; Delgado, Antonio. The article contains the following contents:
A series of potential active-site sphingosine-1-phosphate lyase (S1PL) inhibitors have been designed from scaffolds 1 and 2, arising from virtual screening using the X-ray structures of the bacterial (StS1PL) and the human (hS1PL) enzymes. Both enzymes are very similar at the active site, as confirmed by the similar exptl. kinetic constants shown by the fluorogenic substrate RBM13 in both cases. However, the docking scoring functions used probably overestimated the weight of electrostatic interactions between the ligands and key active-site residues in the protein environment, which may account for the modest activity found for the designed inhibitors. In addition, the possibility that the inhibitors do not reach the enzyme active site should not be overlooked. Finally, since both enzymes show remarkable structural differences at the access channel and in the proximity to the active site cavity, caution should be taken when designing inhibitors acting around that area, as evidenced by the much lower activity found in StS1PL for the potent hS1PL inhibitor D. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Synthetic Route of C4H7BrO2)
Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Synthetic Route of C4H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary