In 2016,Uzarewicz-Baig, Magdalena; Wilhelm, Rene published 《Straightforward Diastereoselective Synthesis of P-Chirogenic (1R)-1,8,8-Trimethyl-2,4-diaza-3-phosphabicyclo[3.2.1]octane 3-Oxides: Application as Chiral NMR Solvating Agents》.Heteroatom Chemistry published the findings.Application In Synthesis of 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:
A direct route to enantio- and diastereopure nitrogen-substituted phosphine oxides has been developed. The desired P-stereogenic compounds were obtained in good yields and high purity. The starting point of the synthesis was (+)-camphor, which is a readily available compound from the chiral pool. The new nitrogen-substituted phosphine oxides could be transformed from their pentavalent state to their trivalent form with N,O-bis(trimethylsilyl)acetamide, which makes them potential chiral ligands. It was possible to apply these compounds as chiral-solvating agents in chiral recognition experiments with a racemic alc. and acid. In addition to this study using 1-Bromo-2-isopropylbenzene, there are many other studies that have used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Application In Synthesis of 1-Bromo-2-isopropylbenzene) was used in this study.
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application In Synthesis of 1-Bromo-2-isopropylbenzene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary