The author of 《Clickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: A significant breakthrough for the construction of amides and peptide linkages》 were Wang, Shi-Meng; Zhao, Chuang; Zhang, Xu; Qin, Hua-Li. And the article was published in Organic & Biomolecular Chemistry in 2019. Electric Literature of C7H5BrO2 The author mentioned the following in the article:
A mild, simple, efficient and robust protocol was developed for the synthesis of amides RC(O)NR1R2 [R = Et, Ph, 2-furyl, 4-pyridyl, etc., R1 = H, Et, Bn, etc., R2 = Et, Ph, 3-pyridyl, etc.] via SO2F2-mediated clickable coupling of carboxylic acids with amines. Peptide linkages were also prepared using this methodol. The direct click reactions of acids and amines on gram scale were also demonstrated using an extremely easy work-up and purification process of washing with 1 M aqueous HCl to provide the desired amides in greater than 99% purity and excellent yields. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Electric Literature of C7H5BrO2)
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Electric Literature of C7H5BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary