Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Electric Literature of 4224-70-8.
Fang, Xiong;Meng, Qian;Zhang, Huijun;Fang, Xiao;Huang, Lina S.;Zhang, Xingquan;Schooley, Robert T.;Ciechanover, Aaron;An, Jing;Xu, Yan;Huang, Ziwei research published ã?A fragment integrational approach to GPCR inhibition: Identification of a high affinity small molecule CXCR4 antagonistã? the research content is summarized as follows. Here, employed a fragment integrational approached, designed and synthesized a new and potent small mol. CXCR4 antagonist (named as HF51116 I), as well as a fluorescent (FITC)-labeled HF51116 I (FITC-HF51116 I). I exhibited very high CXCR4 binding affinity with IC50 of 12 nM in competitive binding with a CXCR4 specific antibody 12G5, which was comparable to the wild type chemokines or synthetic peptides of much larger mol. sizes. Direct binding measurement using FITC-HF51116 I further revealed the compound’s high CXCR4 affinity. HF51116 I strongly antagonized SDF-1α-induced cell migration, calcium mobilization, and CXCR4 internalization. Furthermore, HF51116 I inhibited HIV-1 infection via CXCR4, demonstrating its antiviral therapeutic potential. The mechanism of HF51116 I-CXCR4 interaction was analyzed by site-directed mutagenesis and mol. modeling which suggested that the compound recognized the minor and major subpockets of CXCR4. Its binding to CXCR4 was found to block G protein-dependent downstream signal pathways as detected by luciferase reporter assays. With its potent bioactivities and asym. structure amenable to chem. diversification, HF51116 I may serve as a prototype for developing a new class of CXCR4-targeted therapeutics and proof of the concept of similar strategies for studying other GPCRs.
Electric Literature of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary