A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Recommanded Product: 4-Bromobenzene-1,2-diamine.
Fayed, Eman a.;Ammar, Yousry a.;Saleh, Marwa a.;Bayoumi, Ashraf h.;Belal, Amany;Mehany, Ahmed b. m.;Ragab, Ahmed research published ã?Design, synthesis, antiproliferative evaluation, and molecular docking study of new quinoxaline derivatives as apoptotic inducers and EGFR inhibitorsã? the research content is summarized as follows. A new series of quinoxaline derivatives I (R = 6-Br, 6-Cl, 7-PhCO; X = MeO, H2NNH) and II [R = H, 6-Br-6-Cl-7-PhCO; X = HO, MeO, EtO, H2NNH, PhC(O)NHNH, 4-MeC6H4CH:NNH, etc.] were synthesized and pharmacol. evaluated against HepG-2, HCT-116, and MCF-7 cell lines. Seven compounds I (R = 6-Cl, 6-Br; X = H2NNH), II (R = 6-Cl, 6-Br, 7-PhCO, X = MeO; R = 6-Cl, X = EtO) and 3,4-dihydro-2H-pyrano[2,3-b]quinoxalin-2-one were found to possess the highest activities against the examined cell lines with IC50 values ranging from (7.57 to 28.44μM). These compounds were further selected to analyze their apoptotic potential in MCF-7 cells. Interestingly, it was found that the Bcl-2 level decreased by 1.95-3.99 times and the BAX level increased by 7.2-10.6 times relative to the control. These compounds also increased the active Caspase-3 level by 5.77-10.69 folds compared to untreated cells. WI-38 cells were treated with these compounds to estimate the cytotoxicity level of in non-tumorigenic cells, and these compounds displayed higher IC50 values (142.21-335.03μM). Further studies on the mechanism of the most promising compounds I (R = 6-Br; X = H2NNH), II (R = 6-Cl, 6-Br; X = MeO) and 3,4-dihydro-2H-pyrano[2,3-b]quinoxalin-2-one, revealed that they increase apoptotic cells and induce cell cycle arrest at pre-G1 and G2/M phases. Besides, evaluation of both wild EGFRWT and mutant EGFRL858R-TK inhibitory activity for these derivatives showed IC50 values ranging from 0.075-1.547μM vs. wild EGFRWT and 63.70-87.34 nM vs. the mutant type. Erlotinib was used as a standard reference with IC50 values of 0.0656μM and 59.56 nM vs. both types. Finally, the mol. docking study of most potent quinoxaline derivatives exhibited a good binding inside the active site of EGFR (1M17), with binding energy ranged between (-15.86 to -16.97) compared to Erlotinib (-17.84) kcal/mol. Also, by applying Lipinski’s parameters, it was found that these derivatives showed no violations and indicated possibility to formulate orally.
1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Recommanded Product: 4-Bromobenzene-1,2-diamine
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary