A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Electric Literature of 1575-37-7.
Gawandi, Sinthiya J.;Desai, Vidya G.;Joshi, Shrinivas;Shingade, Sunil;Pissurlenkar, Raghuvir R. research published 《 Assessment of elementary derivatives of 1,5-benzodiazepine as anticancer agents with synergy potential》, the research content is summarized as follows. Herein, we designed and synthesized 1,5-benzodiazepines as a lead mol. for anticancer activity and as potent synergistic activity with drug Methotrexate. Working under the framework of green chem. principles, series of 1,5-benzodiazepine derivatives (3a-3a1) were synthesized using biocatalyst i.e. thiamine hydrochloride under solvent free neat heat conditions. These compounds were screened for in vitro anti cancer activity against couple of cancer cell lines (HeLa and HEPG2) and normal human cell line HEK-293 via MTT assay. Compound 3x was found to be influential against both the cell lines with IC50 values of 0.067 ± 0.002 μM against HeLa and 0.087 ± 0.003 μM against HEPG2 cell line, having activity as compatible to the standard drug Methotrexate. Bioinformatic anal. showed that these compounds are good tyrosine kinase inhibitors which was then proved using enzyme inhibition assay. The studies of apoptosis revealed late apoptotic mode of cell death for the compounds against HEPG2 cancer cell line using flow cytometry method. Synergistic studies of compound 3x and drug Methotrexate showed that the combination was highly active against cancer HeLa and HEPG2 cell line with IC50 value 0.046 ± 0.002 μM and 0.057 ± 0.002 μM resp., which was well supported by apoptosis pathway. Further the compounds proved its scope as DNA intercalating agents, as its mol. docking and DNA binding studies revealed that the compounds would fit well into the DNA strands.
1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Electric Literature of 1575-37-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary