Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application of C2H7Br2N.
Guan, Ya;Gao, Ning;Niu, Hong;Dang, Yu;Guan, Jianjun research published 《 Oxygen-release microspheres capable of releasing oxygen in response to environmental oxygen level to improve stem cell survival and tissue regeneration in ischemic hindlimbs》, the research content is summarized as follows. Stem cell transplantation has been extensively explored to promote ischemic limb vascularization and skeletal muscle regeneration. Yet the therapeutic efficacy is low due to limited cell survival under low oxygen environment of the ischemic limbs. Therefore, continuously oxygenating the transplanted cells has potential to increase their survival. During tissue regeneration, the number of blood vessels are gradually increased, leading to the elevation of tissue oxygen content. Accordingly, less exogenous oxygen is needed for the transplanted cells. Excessive oxygen may induce reactive oxygen species (ROS) formation, causing cell apoptosis. Thus, it is attractive to develop oxygen-release biomaterials that are responsive to the environmental oxygen level. Herein, we developed oxygen-release microspheres whose oxygen release was controlled by oxygen-responsive shell. The shell hydrophilicity and degradation rate decreased as the environmental oxygen level increased, leading to slower oxygen release. The microspheres were capable of directly releasing mol. oxygen, which are safer than those oxygen-release biomaterials that release hydrogen peroxide and rely on its decomposition to form oxygen. The released oxygen significantly enhanced mesenchymal stem cell (MSC) survival without inducing ROS production under hypoxic condition. Co-delivery of MSCs and microspheres to the mouse ischemic limbs ameliorated MSC survival, proliferation and paracrine effects under ischemic conditions. It also significantly accelerated angiogenesis, blood flow restoration, and skeletal muscle regeneration without provoking tissue inflammation. The above results demonstrate that the developed microspheres have potential to augment cell survival in ischemic tissues, and promote ischemic tissue regeneration in a safer and more efficient manner.
2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., Application of C2H7Br2N
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary