One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid, Product Details of C6H11BrO2
Hensbergen, Albertus W.;de Kleer, Mathijs A. C.;Boutkan, Michael S.;van Willigen, Danny M.;van der Wijk, Felicia A.;Welling, Mick M.;Wester, Hans-Jurgen;Buckle, Tessa;van Leeuwen, Fijs W. B. research published 《 Evaluation of asymmetric orthogonal cyanine fluorophores》, the research content is summarized as follows. Pentamethine cyanine (Cy5) fluorophores proved to be versatile imaging agents (i.e., tracers) for a range of micro- and macroscopic imaging applications, including image-guided surgery. The relation between the structure of asym. Cy5 fluorophores and their photophys. properties was studied. To this end, seven Cy5 analogs, bearing orthogonal N-indole substituents (H, SO3–, or benzene), were synthesized and evaluated. In-depth anal. revealed that introduction of sulfonates enhanced the fluorescence brightness and photostability, while reducing the lipophilicity, serum binding and stacking tendency. The addition of benzene moieties induced a bathochromic shift of 10-20 nm, increased the lipophilicity (LogP = -1.56-1.23) and serum binding (67.3-93.8% bound), as well as neg. impacted the brightness (0.74-42.9 × 103 M-1 cm-1), photostability (24.4-90.6% remaining), and stacking tendency. Chem. stability was uninfluenced by the substitution pattern. Addnl., the generation of a c[RGDyK]-based hybrid tracer based on one of these fluorophores in combination with a diethylenetriaminepentaacetic acid (DTPA) chelate and an 111In-isotope is reported. This compound was evaluated in vitro using αvβ3-overexpressing Geβ3 cells and in vivo using a 4T1 mouse tumor model. Overall, the presented results imply that alterations of the asym. orthogonal Cy5 fluorophore structure have impact on the (photo)phys. properties. Furthermore, the orthogonal Cy5 fluorophore framework can readily be applied in tracer development.
Product Details of C6H11BrO2, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary