Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 2576-47-8, formula is C2H7Br2N, The most pervasive is the naturally produced bromomethane. Synthetic Route of 2576-47-8
Ho, Vuong Thi Thanh Xuan;Park, Haebeen;An, Seeun;Kim, Gun;Ly, Nguyen Hoang;Lee, So Yeong;Choo, Jaebum;Jung, Hyo Sung;Joo, Sang-Woo research published 《 Coumarin-lipoic acid conjugates on silver nanoparticle-supported nanopipettes for in situ dual-mode monitoring of intracellular Cu(II) and potential chemodynamic therapy applications》, the research content is summarized as follows. Intracellular Cu(II) in the human body is essential to many physiol. functions, and its disruption is connected to several diseases. Synthetic coumarin-lipoic acid (Cou-LA) conjugate-functionalized silver-nanoparticles decorated on nanopipettes (CSNs) were fabricated herein for the determination of intracellular Cu(II) via in situ dual Raman/fluorescence spectroscopy. The CSNs selectively sensed Cu(II) over other metal ions to induce enhanced Raman intensities and fluorescence quenching. The determination of Cu(II) in single HeLa cells was achieved in accordance with changes in the ratio of Raman intensities at 500 and 597 cm-1 and fluorescence at 469 nm, which was ascribed to the capturing of Cu(II) by the CSNs. The Raman signals exhibited a good linear relationship with Cu(II) concentration from 10 to 75 μM with R2 = 0.956. The calibration curve indicated a local Cu(II) concentration of ∼42.6 ± 8.6 μM in a single HeLa cell after pretreatment with 100 μM Cu(II) for 1 h. Cou-LA exhibited negligible cytotoxicity in both normoxic and hypoxic HeLa cells. However, a significant reduction in cell viability occurred with the Cu(II)-Cou-LA complex. This cytotoxicity was attributed to the generation of reactive oxygen species via a Cu-catalyzed Fenton-like process in tumor microenvironments and was found to be applicable to chemodynamic therapy (CDT). The system fabricated in this study represents a novel strategy for intracellular dual-mode Cu(II) detection and CDT applications in cancer research.
Synthetic Route of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary